ASB2 and TRIP11

		ASB2	TRIP11
Description		ankyrin repeat and SOCS box containing 2	thyroid hormone receptor interactor 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Z Disc	Golgi Membrane Acrosomal Membrane Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Cilium Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Transcription Coactivator Activity Protein Binding Small GTPase Binding
	Biological Process	Heart Looping Ubiquitin-dependent Protein Catabolic Process Signal Transduction Skeletal Muscle Atrophy Protein Ubiquitination Actin Cytoskeleton Organization Intracellular Signal Transduction Skeletal Muscle Cell Differentiation Dendritic Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development Podosome Assembly Regulation Of Barbed-end Actin Filament Capping	Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of DNA-templated Transcription Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Bone Development Protein Transmembrane Transport Golgi Ribbon Formation Vesicle Tethering To Golgi
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs
Diseases			Achodrogenesis type IA
GWAS		Aspartate aminotransferase levels ( 33547301) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Sum eosinophil basophil counts ( 27863252)	Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) FEV1 ( 30804560) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391951 31562340 28552196 18391950 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)
Interacting Genes		6 interacting genes: ELOB FLNA FLNB SMAD9 UBC UBE2D1	9 interacting genes: ARNT ATXN1L DSCAM MYBPC2 PSMC5 RB1 SNCA THRA WDR37
Entrez ID		51676	9321
HPRD ID		05768	05143
Ensembl ID		ENSG00000100628	ENSG00000100815
Uniprot IDs		Q96Q27	Q15643
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification Process Glycoprotein Ib-IX-V Complex Cell Cortex Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Actin Filament Binding Protein Localization To Bicellular Tight Junction Epithelial Cell Development Cytoplasm Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Formation Of Radial Glial Scaffolds Tubulin Deacetylation Cell Morphogenesis Z Disc Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Myb Complex Protein Metabolic Process Establishment Of Sertoli Cell Barrier SMAD Protein Complex Target-directed MiRNA Degradation Protein Modification By Small Protein Conjugation Elongin Complex VCB Complex Protein Ubiquitination Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Vesicle Tethering To Golgi	Regulation Of Protein-containing Complex Assembly General Transcription Initiation Factor Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Growth Cone Dendritic Cell Migration Negative Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Inclusion Body TBP-class Protein Binding Locomotory Behavior Phosphoprotein Binding Regulation Of Phosphorus Metabolic Process Nuclear Receptor Activity Social Behavior Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Interleukin-22 Production Regulation Of Actin Filament Organization Skeletal Muscle Cell Differentiation Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Phosphate Metabolic Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Organelle Organization Nuclear Proteasome Complex Striated Muscle Cell Differentiation Erythrocyte Differentiation Transcription By RNA Polymerase II Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Adult Locomotory Behavior Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Negative Regulation Of DNA-templated Transcription Thyrotropin-releasing Hormone Receptor Binding Negative Regulation Of RNA Biosynthetic Process Chromatin Lock Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity
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