TRIM33 and VTCN1

Data Source: HiPPIP (Novel)

		TRIM33	VTCN1
Name		tripartite motif containing 33	V-set domain containing T cell activation inhibitor 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Co-SMAD Binding R-SMAD Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription	Response To Protozoan Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Positive Regulation Of Interleukin-2 Production Positive Regulation Of T Cell Proliferation Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Germ layer formation at gastrulation	None
GWAS		Autism ( 24189344 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Chronotype ( 30696823 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet distribution width ( 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 )	Arthritis (juvenile idiopathic) ( 19116933 ) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 )
Novel Interactors		2 novel interactors: RASGRP1 VTCN1	1 novel interactors: TRIM33
Interacting Genes		14 interacting genes: CEBPA CHD1L CTNNB1 E2F4 ERG H3C1 NLGN3 RSPH1 SMAD3 TRIM24 UBE2D2 UBE2D3 UBE2E1 UBE2N	1 interacting genes: BTLA
Entrez ID		51592	79679
HPRD ID		10423	06429
Ensembl ID		ENSG00000197323	ENSG00000134258
Uniprot IDs		B3KN30 Q9UPN9	Q7Z7D3
PDB IDs		3U5M 3U5N 3U5O 3U5P 5MR8 7ZDD 8BD8 8BD9 8BDY	4GOS
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Chromatin Binding Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Receptor Binding Protein Ubiquitination Nucleoplasm Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation Embryonic Foregut Morphogenesis Transcription Regulator Complex Post-translational Protein Modification Osteoblast Development I-SMAD Binding Positive Regulation Of Macromolecule Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Metabolic Process Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein-containing Complex Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Development Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Organ Development	None