FAM8A1 and CD83

Data Source: HiPPIP (Novel)

		FAM8A1	CD83
Name		family with sequence similarity 8 member A1	CD83 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	ERAD Pathway	Immune System Process Defense Response Humoral Immune Response Signal Transduction Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
GWAS		Idiopathic intracranial hypertension ( 29608535 )	Breast cancer and/or colorectal cancer ( 29698419 ) California verbal learning test score ( 31596458 ) Chronotype ( 30696823 ) Obesity-related traits ( 23251661 ) Response to tofacitinib treatment (herpes zoster) ( 33455090 ) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090 ) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090 ) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090 ) Rheumatoid arthritis ( 22446963 24390342 30423114 )
Novel Interactors		4 novel interactors: CD83 GMPR H4C13 SLC17A4	8 novel interactors: FAM8A1 GCM2 GMPR KIF13A NOL7 PAPSS2 SACS SPP1
Interacting Genes		1 interacting genes: ATP13A2	2 interacting genes: EIF4E FATE1
Entrez ID		51439	9308
HPRD ID		13316	05170
Ensembl ID		ENSG00000137414	ENSG00000112149
Uniprot IDs		Q9UBU6	A0A087WX61 Q01151
PDB IDs		Not available	5MIX 5MJ0 5MJ1 5MJ2
GO Terms Enriched among Interactors		GMP Reductase Activity GMP Reductase Complex Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Cupric Ion Binding Negative Regulation Of Interleukin-4 Production Urate Transport Urate Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Sodium-dependent Phosphate Transport Regulation Of Chaperone-mediated Autophagy Polyamine Transmembrane Transport Cellular Response To Manganese Ion Sodium:phosphate Symporter Activity Thyroid Hormone Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion	Eukaryotic Initiation Factor 4G Binding GMP Reductase Activity GMP Reductase Complex Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Estradiol Secretion