FAM8A1 and GMPR

		FAM8A1	GMPR
Description		family with sequence similarity 8 member A1	guanosine monophosphate reductase
Image		No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Membrane	Cytosol GMP Reductase Complex
	Molecular Function	Protein Binding	Catalytic Activity GMP Reductase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	ERAD Pathway	Purine Nucleobase Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Response To Cold
Pathways			Purine salvage Regulation of MITF-M dependent genes involved in invasion
Drugs			Guanosine-5'-Monophosphate
Diseases
GWAS		Idiopathic intracranial hypertension ( 29608535)	Gambling ( 22780124) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29874175 24952745) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		1 interacting genes: ATP13A2
Entrez ID		51439	2766
HPRD ID		13316	00754
Ensembl ID		ENSG00000137414	ENSG00000137198
Uniprot IDs		Q9UBU6	P36959
PDB IDs			2BLE 2BWG
Enriched GO Terms of Interacting Partners?		GMP Reductase Activity GMP Reductase Complex Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Cupric Ion Binding Negative Regulation Of Interleukin-4 Production Urate Transport Urate Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Sodium-dependent Phosphate Transport Regulation Of Chaperone-mediated Autophagy Polyamine Transmembrane Transport Cellular Response To Manganese Ion Sodium:phosphate Symporter Activity Thyroid Hormone Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion	Ripoptosome Positive Regulation Of MiRNA Processing Death-inducing Signaling Complex Positive Regulation Of Interleukin-6-mediated Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Leukocyte Differentiation Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Interleukin-4 Production Hrd1p Ubiquitin Ligase Complex Positive Regulation Of Cell Development JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Hemopoiesis Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Cytokine Production Positive Regulation Of Macrophage Differentiation Regulation Of MiRNA Processing Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Necroptotic Process Regulation Of Regulatory NcRNA Processing Death Receptor Binding Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Protein Catabolic Process Negative Regulation Of Programmed Necrotic Cell Death Amyloid Fibril Formation Regulation Of Macrophage Differentiation T Cell Apoptotic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Regulation Of Necroptotic Process Regulation Of Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Lymphocyte Apoptotic Process Response To Stress Regulation Of Programmed Necrotic Cell Death Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-2 Production Regulation Of Cell Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Cell Differentiation Positive Regulation Of Interleukin-10 Production Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Leukocyte Apoptotic Process
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