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ATP5E and CYP17A1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
ATP5E
CYP17A1
Gene Name
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
cytochrome P450, family 17, subfamily A, polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Core F(1)
Mitochondrial Proton-transporting ATP Synthase Complex
Mitochondrial Matrix
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Axon
Neuronal Cell Body
Molecular Function
ATPase Activity
Transmembrane Transporter Activity
Proton-transporting ATP Synthase Activity, Rotational Mechanism
Proton-transporting ATPase Activity, Rotational Mechanism
Steroid 17-alpha-monooxygenase Activity
Iron Ion Binding
Oxygen Binding
Heme Binding
17-alpha-hydroxyprogesterone Aldolase Activity
Biological Process
Respiratory Electron Transport Chain
Mitochondrial ATP Synthesis Coupled Proton Transport
Cellular Metabolic Process
Small Molecule Metabolic Process
Steroid Biosynthetic Process
Androgen Biosynthetic Process
Glucocorticoid Biosynthetic Process
Xenobiotic Metabolic Process
Sex Differentiation
Steroid Metabolic Process
Response To Herbicide
Response To Acetate
Response To Ionizing Radiation
Sterol Metabolic Process
Response To Insecticide
Biphenyl Metabolic Process
Dibenzo-p-dioxin Metabolic Process
Phenol-containing Compound Metabolic Process
Phthalate Metabolic Process
Hippocampus Development
Adrenal Gland Development
Ovulation
Response To Nutrient Levels
Response To Retinoic Acid
Leydig Cell Differentiation
Response To Cytokine
Hormone Biosynthetic Process
Progesterone Metabolic Process
Response To Drug
Small Molecule Metabolic Process
Response To Steroid Hormone
Response To CAMP
Response To Methylmercury
Oxidation-reduction Process
Response To Fungicide
Cellular Response To Lipopolysaccharide
Cellular Response To Antibiotic
Cellular Response To Gonadotropin Stimulus
Positive Regulation Of Steroid Hormone Biosynthetic Process
Pathways
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Formation of ATP by chemiosmotic coupling
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Glucocorticoid biosynthesis
Metabolic disorders of biological oxidation enzymes
Androgen biosynthesis
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Phase 1 - Functionalization of compounds
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Biological oxidations
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Metabolism of steroid hormones and vitamin D
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
NADH
Progesterone
Abiraterone
Diseases
GWAS
Blood pressure (
21572416
21909110
)
Coronary heart disease (
21378990
)
Parkinson's disease (
19915575
)
Prostate cancer (
23535732
)
Systolic blood pressure (
19430479
19430483
21909115
)
Protein-Protein Interactions
1 interactors:
CYP17A1
8 interactors:
ATP5E
BARX1
CDO1
CYB5A
HSP90AB1
POR
RPAIN
TIGD7
Entrez ID
514
1586
HPRD ID
05856
01944
Ensembl ID
ENSG00000148795
Uniprot IDs
P56381
P05093
Q1HB44
PDB IDs
2C17
3RUK
3SWZ
Enriched GO Terms of Interacting Partners
?
Response To Acetate
Response To Fungicide
Phthalate Metabolic Process
Glucocorticoid Biosynthetic Process
Response To Herbicide
Positive Regulation Of Steroid Hormone Biosynthetic Process
Response To Methylmercury
Dibenzo-p-dioxin Metabolic Process
Biphenyl Metabolic Process
Positive Regulation Of Hormone Biosynthetic Process
Androgen Biosynthetic Process
Glucocorticoid Metabolic Process
Response To Insecticide
Leydig Cell Differentiation
Cellular Response To Antibiotic
Ovulation
Progesterone Metabolic Process
Cellular Response To Toxic Substance
Cellular Response To Gonadotropin Stimulus
Regulation Of Hormone Biosynthetic Process
Positive Regulation Of Steroid Metabolic Process
C21-steroid Hormone Metabolic Process
Regulation Of Hormone Metabolic Process
Androgen Metabolic Process
Adrenal Gland Development
Response To Gonadotropin
Hormone Biosynthetic Process
Response To Antibiotic
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Steroid Biosynthetic Process
Hippocampus Development
Cellular Ketone Metabolic Process
Dicarboxylic Acid Metabolic Process
Regulation Of Steroid Metabolic Process
Phenol-containing Compound Metabolic Process
Limbic System Development
Female Gamete Generation
Steroid Biosynthetic Process
Response To CAMP
Response To Retinoic Acid
Sterol Metabolic Process
Regulation Of Lipid Biosynthetic Process
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Response To Ionizing Radiation
Response To Xenobiotic Stimulus
Response To Organophosphorus
Cellular Response To Lipopolysaccharide
Male Gonad Development
Cellular Response To Molecule Of Bacterial Origin
Cellular Organofluorine Metabolic Process
Nitrate Catabolic Process
Nitric Oxide Catabolic Process
Oxidation-reduction Process
Regulation Of Growth Plate Cartilage Chondrocyte Proliferation
Taurine Biosynthetic Process
Nitrate Metabolic Process
L-cysteine Catabolic Process
Hydrogen Ion Transmembrane Transport
Proton Transport
Positive Regulation Of Cholesterol Biosynthetic Process
Taurine Metabolic Process
Positive Regulation Of Cholesterol Metabolic Process
Positive Regulation Of Steroid Hormone Biosynthetic Process
Cysteine Metabolic Process
Carboxylic Acid Metabolic Process
Small Molecule Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Hormone Biosynthetic Process
Organic Acid Metabolic Process
Positive Regulation Of Protein Import Into Nucleus, Translocation
L-ascorbic Acid Metabolic Process
Carnitine Metabolic Process
Negative Regulation Of Proteolysis
Sulfur Amino Acid Catabolic Process
Serine Family Amino Acid Catabolic Process
Cellular Response To Follicle-stimulating Hormone Stimulus
Positive Regulation Of Cell Size
Negative Regulation Of Protein Processing
Mitochondrial ATP Synthesis Coupled Proton Transport
Amino-acid Betaine Metabolic Process
Regulation Of Protein Import Into Nucleus, Translocation
Negative Regulation Of Lipase Activity
Regulation Of Cholesterol Biosynthetic Process
Transport
Regulation Of Protein Processing
Tagcloud
?
acth
adrenal
adrenocortical
adrenocorticotropin
belongs
biosynthesis
camp
confers
cortisol
dbhs
exoribonuclease
export
facilitating
glucocorticoid
h295r
isoforms
nono
p54nrb
pde
pde11a
pde2a
pde3a
pde3b
pde4a
pde4d
phosphodiesterase
select
splicing
xrn2
Tagcloud (Difference)
?
acth
adrenal
adrenocortical
adrenocorticotropin
belongs
biosynthesis
camp
confers
cortisol
dbhs
exoribonuclease
export
facilitating
glucocorticoid
h295r
isoforms
nono
p54nrb
pde
pde11a
pde2a
pde3a
pde3b
pde4a
pde4d
phosphodiesterase
select
splicing
xrn2
Tagcloud (Intersection)
?