GOLM1 and SLC40A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		GOLM1	SLC40A1
Description		golgi membrane protein 1	solute carrier family 40 member 1
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Nucleus Organization Regulation Of Lipid Metabolic Process	Lymphocyte Homeostasis Endothelium Development Transcription By RNA Polymerase II Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Apoptotic Process Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Establishment Of Localization In Cell Transmembrane Transport Spleen Trabecula Formation Multicellular Organismal-level Iron Ion Homeostasis Iron Ion Export Across Plasma Membrane
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Blood protein levels ( 30072576) Logical memory (delayed recall) in normal cognition ( 29274321)	Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 25352340 33536631) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935) Liver iron content ( 34128465) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494) Restless legs syndrome ( 33239738)
Interacting Genes		76 interacting genes: ABI3 AIG1 ANKRD46 ASPH B3GNT4 BCL2L1 C1orf174 C1QL4 CDIPT CIAO1 CLDN4 CLDND2 CLK1 CNPY3 DCK DCTN2 DESI1 DEXI EFTUD2 EIF2B3 EIF3J ELAC2 FLOT1 FTH1 FUT9 GALNT15 GAST GEMIN7 GET3 GLB1 GRIK5 GUCA2A HGFAC HMGB1 HSD17B13 IGFBP5 INSIG2 JAGN1 KCNE3 LAT LSM12 MED22 MIP NDUFV2 NEU1 NINJ1 NIPSNAP3A NRSN2 PGRMC1 RACK1 RIPPLY2 RPA2 RPL13A SFTPC SLC13A5 SLC30A3 SLC40A1 SLC5A4 SLCO3A1 ST6GAL2 STRIT1 SYT1 TF THSD7A TMEM109 TMEM140 TMEM147 TMEM176A TMEM86B TMEM98 TMPO TMUB1 TMUB2 TSG101 VSTM1 ZFAND3	3 interacting genes: GOLM1 HAMP SLC22A2
Entrez ID		51280	30061
HPRD ID		08428	05229
Ensembl ID		ENSG00000135052	ENSG00000138449
Uniprot IDs		B3KNK9 Q8NBJ4	Q9NP59
PDB IDs		8YBC	6W4S 6WBV 8BZY 8C02 8C03 8DL6 8DL7 8DL8
Enriched GO Terms of Interacting Partners?		Membrane	Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Export Across Plasma Membrane Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Peptidyl-lysine N6-acetylation L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Iron Export Across Plasma Membrane Negative Regulation Of Iron Ion Transmembrane Transport Iron Ion Transmembrane Transporter Inhibitor Activity Negative Regulation Of Intestinal Absorption Negative Regulation Of Iron Ion Transport Iron Ion Export Across Plasma Membrane Transporter Regulator Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Iron Ion Transport Toxin Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Choline Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Norepinephrine Transport Histamine Transport L-arginine Transmembrane Transporter Activity Internal Peptidyl-lysine Acetylation Positive Regulation Of Receptor Catabolic Process Organic Cation Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity L-arginine Transmembrane Transport Amine Transport Catecholamine Uptake Dopamine Uptake Internal Protein Amino Acid Acetylation Azole Transmembrane Transport
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