GLTP and MVK

		GLTP	MVK
Description		glycolipid transfer protein	mevalonate kinase
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Peroxisome Cytosol
	Molecular Function	Protein Binding Lipid Binding Glycolipid Transfer Activity Identical Protein Binding Glycolipid Binding Lipid Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity	Nucleotide Binding Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Transport Ceramide Transport Response To Immobilization Stress Glycolipid Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Negative Regulation Of Inflammatory Response
Pathways		Glycosphingolipid transport	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Lauric acid Sphingosine Capric acid Lactose	Farnesyl thiopyrophosphate
Diseases			Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Bipolar disorder ( 31043756) Hemoglobin ( 32888494) Metabolic syndrome ( 20694148)	Aspartate aminotransferase levels ( 29403010) Cataracts ( 34127677) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 19060906 30275531 25961943 24097068 20864672 20686565 18193043) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414) Serum metabolite levels ( 33031748)
Interacting Genes		2 interacting genes: CEBPA CMTM5	5 interacting genes: CEBPA EWSR1 POT1 RNF141 TERF1
Entrez ID		51228	4598
HPRD ID		16409	02015
Ensembl ID		ENSG00000139433	ENSG00000110921
Uniprot IDs		Q9NZD2	B2RDU6 B7Z1C2 B7Z301 F5H8H2 Q03426
PDB IDs		1SWX 1SX6 2EUK 2EUM 2EVD 2EVL 2EVS 2EVT 3RIC 3RWV 3RZN 3S0I 3S0K 4GH0 4GHP 4GHS 4GIX 4GJQ 4GVT 4GXD 4GXG 4H2Z	2R3V
Enriched GO Terms of Interacting Partners?		Sterol Metabolic Process Cholesterol Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Mevalonate Kinase Activity Response To Vitamin B2 C/EBP Complex CHOP-C/EBP Complex Steroid Metabolic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Alcohol Metabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Isopentenyl Diphosphate Biosynthetic Process Isopentenyl Diphosphate Metabolic Process Response To Phenylpropanoid Fat Cell Proliferation Regulation Of Inflammatory Response Urea Metabolic Process HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Hematopoietic Stem Cell Proliferation Negative Regulation Of Cell Differentiation Embryonic Placenta Development Epithelial Cell Maturation Isoprenoid Biosynthetic Process Negative Regulation Of Myoblast Differentiation Acetyl-CoA Metabolic Process Cholesterol Biosynthetic Process Regulation Of Defense Response Integrated Stress Response Signaling Acute-phase Response Sterol Biosynthetic Process Response To Dexamethasone Macrophage Differentiation	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Inner Ear Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Clathrin Coat Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Intestinal Epithelial Cell Migration Leukocyte Adhesive Activation Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly DNA Biosynthetic Process Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Regulation Of Protein-containing Complex Assembly Cerebellar Cortex Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Clathrin Coat Assembly 8-hydroxy-2'-deoxyguanosine DNA Binding
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