GPN3 and GTPBP2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GPN3	GTPBP2
Name		GPN-loop GTPase 3	GTP binding protein 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein-containing Complex	Extracellular Region Platelet Alpha Granule Lumen
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Identical Protein Binding Alpha-aminoacyl-tRNA Binding
	Biological Process	None	Translational Elongation Nuclear-transcribed MRNA Catabolic Process, No-go Decay Rescue Of Stalled Ribosome
Pathways		None	Platelet degranulation
GWAS		Adult body size ( 32376654 ) Bipolar disorder ( 31043756 )	Adult body size ( 32376654 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Novel Interactors		None recorded	1 novel interactors: CSNK2B
Interacting Genes		1 interacting genes: GTPBP2	12 interacting genes: CLK2 GPN3 KDM1A NXF1 PICK1 PLEKHF2 PRMT5 PRMT6 PSMB1 SNRNP70 SUV39H1 TXN2
Entrez ID		51184	54676
HPRD ID		17498	08465
Ensembl ID		ENSG00000111231	ENSG00000172432
Uniprot IDs		Q9UHW5	A8K2K2 Q9BX10
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Alpha-aminoacyl-tRNA Binding Nuclear-transcribed MRNA Catabolic Process, No-go Decay Translation Elongation Factor Activity Rescue Of Stalled Ribosome Ribosome Disassembly Platelet Alpha Granule Lumen Translational Elongation Organelle Disassembly Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process	Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of MRNA Splicing, Via Spliceosome Histone Methyltransferase Complex Methyltransferase Activity Regulation Of RNA Splicing Chromatin Binding Methylation Positive Regulation Of RNA Splicing Nucleoplasm Cellular Response To Glucose Starvation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Refolding Chromatin Remodeling P53 Binding Peptidyl-arginine N-methylation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphorylation Negative Regulation Of Metabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Chaperone-mediated Autophagy ENoSc Complex Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Nuclear Speck Phosphorylation Macromolecule Metabolic Process Release From Viral Latency Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Secretory Granule Lumen Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Folding Histone H3K9 Trimethyltransferase Activity RDNA Heterochromatin Chromatin Organization Membrane Curvature Sensor Activity Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation