SEPSECS and ANAPC4

		SEPSECS	ANAPC4
Description		Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	anaphase promoting complex subunit 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery
	Molecular Function	TRNA Binding RNA Binding Protein Binding Transferase Activity O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding
	Biological Process	Selenocysteine Incorporation Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec Translation	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Selenocysteine synthesis	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pyridoxal phosphate
Diseases
GWAS		Tonsillectomy ( 27182965 28928442)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Waist circumference adjusted for body mass index ( 34021172) Weight ( 20966902)
Interacting Genes		1 interacting genes: DTX2	5 interacting genes: CCNA1 MAD2L1BP PTTG1 UBE2I UBE2S
Entrez ID		51091	29945
HPRD ID		11561	09505
Ensembl ID		ENSG00000109618	ENSG00000053900
Uniprot IDs		A0A7P0TA23 A1A4F3 Q9HD40	B3KN47 Q9UJX5
PDB IDs		3HL2 4ZDL 4ZDO 4ZDP 7L1T 7MDL 8G9Z	4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Inner Dynein Arm Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Sperm Axoneme Assembly Dynein Complex Protein K11-linked Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Post-translational Protein Modification Protein Branched Polyubiquitination Protein Ubiquitination Nuclear Periphery Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Axoneme Assembly	Cell Division SUMO Conjugating Enzyme Activity O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex RING-like Zinc Finger Domain Binding Chromosome Segregation SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Mitotic Cell Cycle Phase Transition Cyclin A2-CDK2 Complex Cell Cycle Phase Transition Homologous Chromosome Segregation Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Ubiquitin Protein Ligase Activity Nucleus Free Ubiquitin Chain Polymerization Selenocysteine Incorporation Positive Regulation Of Mitotic Sister Chromatid Segregation Anaphase-promoting Complex Binding Mitotic Nuclear Membrane Reassembly Protein K29-linked Ubiquitination Transferase Complex Positive Regulation Of Ubiquitin-protein Transferase Activity Meiotic Chromosome Segregation Exit From Mitosis Regulation Of Exit From Mitosis Protein K27-linked Ubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-like Protein Transferase Activity Transcription Factor Binding SUMO Transferase Activity Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Synaptonemal Complex Nuclear Membrane Reassembly Molecular Function Activator Activity Protein K6-linked Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Male Meiosis I Presynaptic Cytosol Postsynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Chromosome Segregation Male Gamete Generation
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