TMED5 and KIF21B

		TMED5	KIF21B
Description		transmembrane p24 trafficking protein 5	kinesin family member 21B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	Protein Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Golgi Ribbon Formation	Microtubule-based Movement
Pathways		WNT ligand biogenesis and trafficking	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 29403010)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 21743469 23749187) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 21833088) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 19915572 25082827 20228799)
Interacting Genes		3 interacting genes: CXCL9 PRMT6 TMEM132D	6 interacting genes: DMRTB1 NTAQ1 QKI TK1 TRIM3 UBC
Entrez ID		50999	23046
HPRD ID		13028	12211
Ensembl ID		ENSG00000117500	ENSG00000116852
Uniprot IDs		M0R072 Q9Y3A6	O75037 Q2UVF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development TRNA 2'-O-methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Low-density Lipoprotein Receptor Particle Metabolic Process Extrinsic Component Of External Side Of Plasma Membrane PCSK9-AnxA2 Complex Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process PCSK9-LDLR Complex CXCR3 Chemokine Receptor Binding Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Very-low-density Lipoprotein Particle Binding Negative Regulation Of Receptor Recycling Very-low-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Positive Regulation Of Microtubule Nucleation Centriolar Subdistal Appendage Ventral Spinal Cord Development TRNA Methyltransferase Activity Methylation Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Receptor Catabolic Process Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Signaling Receptor Inhibitor Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Sodium Ion Transmembrane Transport
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