PCDHGC3 and HGD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PCDHGC3	HGD
Description		protocadherin gamma subfamily C, 3	homogentisate 1,2-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytosol Extracellular Exosome
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding	Homogentisate 1,2-dioxygenase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Neuron Apoptotic Process Synapse Organization	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tyrosine Metabolic Process L-tyrosine Catabolic Process
Pathways			Tyrosine catabolism
Drugs
Diseases			Alkaptonuria
GWAS		Mean platelet volume ( 32888494)
Interacting Genes		4 interacting genes: APP HGD SLC33A2 TRIM54	5 interacting genes: CLDN7 GIT2 NTAQ1 PCDHGC3 TERF1
Entrez ID		5098	3081
HPRD ID		04693	06315
Ensembl ID		ENSG00000240184	ENSG00000113924
Uniprot IDs		Q9BR81 Q9UN70	B3KW64 Q93099
PDB IDs			1EY2 1EYB
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Homogentisate 1,2-dioxygenase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway L-tyrosine Catabolic Process Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity L-phenylalanine Catabolic Process Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle	Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein-N-terminal Asparagine Amidohydrolase Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping Arachidonate-CoA Ligase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Synaptic Vesicle Recycling Long-chain Fatty Acid-CoA Ligase Activity DNA Binding, Bending Regulation Of ARF Protein Signal Transduction Long-chain Fatty-acyl-CoA Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Apicolateral Plasma Membrane Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process
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