PDCL and EIF3I

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		PDCL	EIF3I
Gene Name		phosducin-like	eukaryotic translation initiation factor 3, subunit I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Receptor Signaling Protein Activity Protein Binding Protein Complex Binding	Translation Initiation Factor Activity Protein Binding
	Biological Process	Protein Folding Signal Transduction Visual Perception Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Refolding Heterotrimeric G-protein Complex Assembly	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways			Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: ADRBK1 CCT5 EIF3I GNB1 IKBKG PSMC5 TCP1	34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM
Entrez ID		5082	8668
HPRD ID		05108	04884
Ensembl ID		ENSG00000136940	ENSG00000084623
Uniprot IDs		Q13371	Q13347 Q5U0F4
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Acetylcholine Receptor Signaling Pathway Toxin Transport Binding Of Sperm To Zona Pellucida Sperm-egg Recognition 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cell-cell Recognition Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Cell Recognition Single Fertilization Fertilization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Inclusion Body Assembly Cardiac Muscle Cell Apoptotic Process Apoptotic Process Negative Regulation Of Striated Muscle Contraction Muscle Cell Apoptotic Process Programmed Cell Death Response To Virus Regulation Of The Force Of Heart Contraction By Chemical Signal Cell Death Death Tachykinin Receptor Signaling Pathway Cellular Metabolic Process Negative Regulation Of Signal Transduction Protein Folding Cellular Protein Metabolic Process Positive Regulation Of Catecholamine Secretion Regulation Of Macrophage Apoptotic Process Negative Regulation Of Signaling Tubulin Complex Assembly Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Inclusion Body Assembly Regulation Of Signal Transduction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		2h2o 4h2o adp adriamycin anticancer antigrowth bax chemotherapeutics cisplatin complexes elucidate far fluorescein iodide isothiocyanate jurkat molt mtt palladium predominately propidium regarded ribose sac satisfactory terpy thp treating warranted	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Difference) ?		2h2o 4h2o adp adriamycin anticancer antigrowth bax chemotherapeutics cisplatin complexes elucidate far fluorescein iodide isothiocyanate jurkat molt mtt palladium predominately propidium regarded ribose sac satisfactory terpy thp treating warranted	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Intersection) ?