CUZD1 and RRM1

		CUZD1	RRM1
Description		CUB and zona pellucida like domains 1	ribonucleotide reductase catalytic subunit M1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Surface Membrane Cytoplasmic Vesicle Zymogen Granule Zymogen Granule Membrane	Nuclear Envelope Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex Centriolar Satellite Ciliary Basal Body Cell Projection Neuronal Cell Body
	Molecular Function		Nucleotide Binding Catalytic Activity Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Oxidoreductase Activity Purine Nucleotide Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Cell Adhesion Trypsinogen Activation Cell Division	DNA Synthesis Involved In DNA Repair Pyrimidine Nucleobase Metabolic Process Mitochondrial DNA Replication DNA Repair Male Gonad Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye Positive Regulation Of G0 To G1 Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS			Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		1 interacting genes: PTPN6	11 interacting genes: BMI1 CDC42 CEBPA LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655
Entrez ID		50624	6240
HPRD ID		06476	01588
Ensembl ID		ENSG00000138161	ENSG00000167325
Uniprot IDs		Q86UP6	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs			2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?		Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Epididymis Development Ribonucleoside-diphosphate Reductase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Regulation Of Inflammatory Response To Wounding Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Phosphorylation-dependent Protein Binding Negative Regulation Of Mast Cell Activation Inflammatory Response To Wounding Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Neutrophil Activation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin CD27 Signaling Pathway Cell Population Proliferation Alpha-beta T Cell Receptor Complex Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Neutrophil Activation Involved In Immune Response Negative Regulation Of Mast Cell Activation Involved In Immune Response Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of B Cell Receptor Signaling Pathway Ribonucleoside-diphosphate Reductase Complex 2'-deoxyribonucleotide Biosynthetic Process Positive Regulation Of G0 To G1 Transition Deoxyribonucleotide Biosynthetic Process Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Cell Proliferation In Forebrain Purine Nucleotide Binding Protein Heterotetramerization Mitochondrial DNA Replication Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Mast Cell Activation Mitochondrial DNA Metabolic Process Pyrimidine Nucleobase Metabolic Process Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Platelet Formation Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Disordered Domain Specific Binding Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Protein Heterooligomerization Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	RING-like Zinc Finger Domain Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Regulation Of Store-operated Calcium Entry PRC1 Complex
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