COL5A3 and COL5A1

Number of citations of the paper that reports this interaction (PMID 10722718)
11

Data Source:
HPRD (in vivo)

		COL5A3	COL5A1
Gene Name		collagen, type V, alpha 3	collagen, type V, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Endoplasmic Reticulum Lumen Extracellular Vesicular Exosome	Extracellular Region Collagen Type V Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Collagen Binding Heparin Binding Proteoglycan Binding	Integrin Binding Extracellular Matrix Structural Constituent Heparin Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Cell-matrix Adhesion Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Skin Development	Blood Vessel Development Heart Morphogenesis Cell Adhesion Axon Guidance Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Extracellular Fibril Organization Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Endodermal Cell Differentiation
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Central corneal thickness ( 22814818 23493294 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Longevity ( 20834067)
Protein-Protein Interactions		2 interactors: COL1A2 COL5A1	10 interactors: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1
Entrez ID		50509	1289
HPRD ID		00369	00368
Ensembl ID		ENSG00000080573	ENSG00000130635
Uniprot IDs		P25940	B2ZZ86 P20908 Q59EE7
PDB IDs			1A89 1A9A
Enriched GO Terms of Interacting Partners?		Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Integrin Biosynthetic Process Skin Development Negative Regulation Of Endodermal Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Development Vasculature Development Wound Healing Tendon Development Response To Wounding Protein Heterotrimerization Extracellular Fibril Organization Wound Healing, Spreading Of Epidermal Cells Collagen Biosynthetic Process Cell Migration Cardiovascular System Development Cell Motility Organ Morphogenesis Negative Regulation Of Embryonic Development Locomotion Protein Trimerization Regulation Of Gastrulation Wound Healing, Spreading Of Cells Movement Of Cell Or Subcellular Component Skin Morphogenesis Rho Protein Signal Transduction Cellular Response To Amino Acid Stimulus Morphogenesis Of An Epithelial Sheet Catabolic Process Response To Amino Acid Regulation Of Embryonic Development Anatomical Structure Morphogenesis Odontogenesis Protein Heterooligomerization Transforming Growth Factor Beta Receptor Signaling Pathway Eye Morphogenesis Cellular Response To Acid Chemical Regulation Of Blood Pressure Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Organ Development Ras Protein Signal Transduction Plasma Membrane Organization	Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Wound Healing Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Blood Coagulation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Hemostasis Negative Regulation Of Phospholipid Biosynthetic Process Platelet Activation Response To External Stimulus Positive Regulation Of Endothelial Cell Migration Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Growth Factor Organ Development Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Endothelial Cell Migration Response To Lipid Positive Regulation Of Protein Autophosphorylation Regulation Of Wound Healing Negative Regulation Of Platelet Activation Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Organ Morphogenesis System Development Response To Steroid Hormone Secretion By Cell Regulation Of Protein Autophosphorylation Regulation Of Cell Migration Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Proliferation Multicellular Organismal Development Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Secretion
Tagcloud ?			acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr
Tagcloud (Difference) ?			acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr
Tagcloud (Intersection) ?