SIX6 and TMEM33

		SIX6	TMEM33
Description		SIX homeobox 6	transmembrane protein 33
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Melanosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis	Immune System Process Response To Endoplasmic Reticulum Stress Innate Immune Response Membrane Organization Endoplasmic Reticulum Tubular Network Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 22419738 33627673 29891935 29452408 22570617 25173105) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 28073927 25631615 31798171) Optic disc area ( 25631615 28073927 31798171) Refractive error ( 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 28073927 31798171 25241763)	Helping behaviour (self reported) ( 29324852) Neurociticism ( 29500382)
Interacting Genes		3 interacting genes: GTF2A1L TLE1 TLE5	3 interacting genes: MTNR1A RPS14 SLC29A2
Entrez ID		4990	55161
HPRD ID		07557	07680
Ensembl ID		ENSG00000184302	ENSG00000109133
Uniprot IDs		O95475 Q6P051	P57088
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Anoikis Transcription Corepressor Activity Positive Regulation Of Anoikis Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of B Cell Receptor Signaling Pathway Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Translation In Response To Stress Transcription Factor TFIIA Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Glial Cell Proliferation Regulation Of B Cell Receptor Signaling Pathway Translation Regulator Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Keratinocyte Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine Kinase Binding Beta-catenin-TCF Complex Negative Regulation Of Anoikis Regulation Of PERK-mediated Unfolded Protein Response Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation	Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Uridine Transmembrane Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity G Protein-coupled Receptor Activity Melatonin Receptor Activity Cytoplasmic Translation Translation Cytosolic Ribosome CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Structural Constituent Of Ribosome Mitochondrial Ribosome Binding Kinase Inhibitor Activity T Cell Differentiation Purine Nucleobase Transmembrane Transport Vesicle Fusion With Golgi Apparatus Mast Cell Activation Membrane Purine Nucleobase Transport Ribosome
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