OAZ2 and SEC11A

		OAZ2	SEC11A
Description		ornithine decarboxylase antizyme 2	SEC11 homolog A, signal peptidase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Ornithine Decarboxylase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Biogenic Amine Metabolic Process Polyamine Metabolic Process Polyamine Biosynthetic Process Positive Regulation Of Protein Catabolic Process Viral Translational Frameshifting Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport	Signal Peptide Processing Proteolysis Response To Virus
Pathways		Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Aluminium levels ( 26025379) Neuroticism ( 29255261)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes		5 interacting genes: BDKRB1 CDR2 OAZ1 ODC1 SYTL3	5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		4947	23478
HPRD ID		11966	07503
Ensembl ID		ENSG00000180304	ENSG00000140612
Uniprot IDs		O95190	H0YKT4 P67812
PDB IDs			7P2P
Enriched GO Terms of Interacting Partners?		Polyamine Biosynthetic Process Polyamine Metabolic Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Biogenic Amine Metabolic Process Amine Metabolic Process Bradykinin Receptor Activity Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine Signal Peptidase Complex Putrescine Biosynthetic Process Viral Translational Frameshifting Putrescine Metabolic Process Signal Peptide Processing Neurexin Family Protein Binding
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