NFATC3 and CALB2

Data Source: HiPPIP (Novel)

		NFATC3	CALB2
Name		nuclear factor of activated T cells 3	calbindin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Nucleus Cytosol Gap Junction Dendrite Stereocilium Cuticular Plate Cell Projection Terminal Bouton Dendriole Synapse Parallel Fiber To Purkinje Cell Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Calcium Ion Binding Metal Ion Binding Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Thymic T Cell Selection Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription DN4 Thymocyte Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Artery Morphogenesis	Intracellular Calcium Ion Homeostasis Regulation Of Synaptic Plasticity Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation	None
Drugs		None	Calcium citrate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate
GWAS		Chronotype ( 30696823 ) Estimated glomerular filtration rate ( 31015462 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 ) Serum alkaline phosphatase levels ( 33547301 ) Urate levels ( 31578528 )	Bipolar disorder ( 34099189 ) Body mass index ( 30271922 ) General risk tolerance (MTAG) ( 30643258 ) Mood instability ( 31168069 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Self-reported risk-taking behaviour ( 30271922 )
Novel Interactors		7 novel interactors: CALB2 CELSR2 KCNJ3 MYOCD SEC24A SNX20 TOR1B	4 novel interactors: CFDP1 CIAO2B IST1 NFATC3
Interacting Genes		7 interacting genes: CDK6 CSNK1A1 FOS IGF2BP3 MAPK8 MAPK9 TTF1	2 interacting genes: KRT1 TUBA4A
Entrez ID		4775	794
HPRD ID		04077	00230
Ensembl ID		ENSG00000072736	ENSG00000172137
Uniprot IDs		B5B2S0 B5B2S1 Q12968	A0A140VK08 A6NER6 P22676
PDB IDs		2XRW 2XS0	Not available
GO Terms Enriched among Interactors		JUN Kinase Activity Parallel Fiber To Purkinje Cell Synapse Protein Serine Kinase Activity NLRP3 Inflammasome Complex Assembly Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway MAP Kinase Activity Protein Serine/threonine Kinase Activity R-SMAD Binding Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Protein Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Oxidative Stress Regulation Of MRNA Stability Regulation Of RNA Stability Cyclin D2-CDK6 Complex Medium-term Memory Cellular Response To Prolactin JUN Phosphorylation Positive Regulation Of MiRNA Transcription Fc Receptor Signaling Pathway Cellular Response To Nutrient Levels JNK Cascade Kinase Activity Positive Regulation Of MiRNA Metabolic Process Cellular Response To Chemical Stress Cellular Senescence Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding I(KACh) Inward Rectifier Potassium Channel Complex Protein Localization To Tricellular Tight Junction Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of MiRNA Transcription Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Neural Plate Anterior/posterior Regionalization Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Metabolic Process Regulation Of MRNA Metabolic Process Termination Of RNA Polymerase I Transcription Regulation Of Cell Growth By Extracellular Stimulus Protein Phosphorylation	Regulation Of Anatomical Structure Morphogenesis