NEK1 and ANXA10

		NEK1	ANXA10
Description		NIMA related kinase 1	annexin A10
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Centriolar Satellite	Nucleus Cytoplasm Plasma Membrane Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Protein Phosphorylation Cell Projection Organization Cell Division Cilium Assembly
Pathways		Regulation of pyruvate metabolism
Drugs		Fostamatinib
Diseases		Short rib-polydactyly syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 25056061 28991256 29483656) Supramarginal gyrus volume ( 31530798)	Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Pursuit maintenance gain ( 29064472) Verbal declarative memory ( 25648963)
Interacting Genes		19 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YAP1 YWHAH ZNF350	2 interacting genes: BLVRB EDC3
Entrez ID		4750	11199
HPRD ID		06847	09724
Ensembl ID		ENSG00000137601	ENSG00000109511
Uniprot IDs		A0A8I5KUL6 Q96PY6	Q9UJ72
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Negative Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Negative Regulation Of Autophagy Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Organelle Assembly Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Vacuole Organization Negative Regulation Of Cell Projection Organization Glutamatergic Synapse DNA Strand Resection Involved In Replication Fork Processing Regulation Of Macroautophagy Negative Regulation Of Catabolic Process Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of Gene Expression Regulation Of Reactive Oxygen Species Metabolic Process Vesicle Membrane Transcription Factor TFIID Complex Replication Fork Regulation Of Cellular Response To Stress Mitochondrial Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Postsynapse Organization Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Endocytosis Glucocorticoid Catabolic Process Clathrin Binding Positive Regulation Of Membrane Permeability	Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity FMN Reductase (NADH) Activity Biliverdin Reductase [NAD(P)H] Activity Chloride:proton Antiporter Activity Peptidyl-cysteine S-nitrosylase Activity
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