MUC2 and NUP98

		MUC2	NUP98
Description		mucin 2, oligomeric mucus/gel-forming	nucleoporin 98 and 96 precursor
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GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Extracellular Matrix Inner Mucus Layer Outer Mucus Layer	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Ribonucleoprotein Complex
	Molecular Function	Protein Binding Cupric Ion Binding Cuprous Ion Binding	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Nuclear Localization Sequence Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Structural Constituent Of Nuclear Pore Peptide Binding Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding
	Biological Process	Detoxification Of Copper Ion Maintenance Of Gastrointestinal Epithelium Host-mediated Modulation Of Intestinal Microbiota Composition Mucus Secretion	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Telomere Tethering At Nuclear Periphery Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Nuclear Pore Complex Assembly
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		Pranlukast Colforsin
Diseases
GWAS		Asthma ( 30929738 31361310 31959851 32296059 34103634) Asthma (adult onset) ( 30929738) Interstitial lung disease ( 23583980) Medication use (adrenergics, inhalants) ( 31015401)	Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)
Interacting Genes		4 interacting genes: GALNT12 GALNT14 MLH1 PLEKHM1	19 interacting genes: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NUP133 NUP188 NUP205 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR
Entrez ID		4583	4928
HPRD ID		11828	03012
Ensembl ID		ENSG00000198788	ENSG00000110713
Uniprot IDs		A0A3S8TMF2 Q02817	A0A8V8TR21 H0YCR0 H0YEN4 P52948
PDB IDs		6RBF 6TM2 6TM6 7A5O 7POV 7PP6 7PRL 7QCL 7QCN 7QCU 8CK2 8S03	1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM 7F60 7F90 7MNI 7PEQ 7Q64 7Q65 7Q66 7Q67 7VPG 7VPH 8CI8
Enriched GO Terms of Interacting Partners?		Telomere Localization Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Organelle Localization Chromosome Localization Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Telomere Tethering At Nuclear Periphery Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protein O-linked Glycosylation Protein Glycosylation Glycosylation Macromolecule Glycosylation Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Pore Cytoplasmic Filaments Carbohydrate Binding Glycosyltransferase Activity Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Glycoprotein Biosynthetic Process Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Autolysosome Membrane Glycoprotein Metabolic Process Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Spindle Midzone Assembly Chromosome Organization Somatic Diversification Of Immune Receptors Via Somatic Mutation Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Nuclear Pore Nuclear Basket Nuclear Inclusion Body Nuclear Pore Organization Positive Regulation Of Ruffle Assembly Autolysosome Autophagosome-lysosome Fusion	Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Envelope RNA Transport Structural Constituent Of Nuclear Pore Protein Localization To Nucleus MRNA Transport Nucleobase-containing Compound Transport Establishment Of Protein Localization To Organelle RNA Export From Nucleus Protein Localization To Organelle Intracellular Transport Nuclear Export Intracellular Protein Transport Protein Transport Nuclear Localization Sequence Binding Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell MRNA Export From Nucleus Intracellular Protein Localization Regulation Of Mitotic Spindle Organization Nuclear Import Signal Receptor Activity Regulation Of Microtubule Cytoskeleton Organization Nucleoplasm Cytosol Nuclear Pore Organization Histone H3K27 Acetyltransferase Activity Regulation Of Cytoskeleton Organization Nucleus Regulation Of Microtubule-based Process Nuclear Membrane Regulation Of Mitotic Spindle Assembly Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nuclear Pore Inner Ring Small GTPase Binding Regulation Of Cell Cycle Kinetochore Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Nucleus Organization Regulation Of Spindle Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus
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