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MTRR and MMAB
Number of citations of the paper that reports this interaction (PMID
15347655
)
18
Data Source:
HPRD
(in vitro)
MTRR
MMAB
Gene Name
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
methylmalonic aciduria (cobalamin deficiency) cblB type
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Intermediate Filament Cytoskeleton
Mitochondrial Matrix
Molecular Function
NADPH-hemoprotein Reductase Activity
Iron Ion Binding
FMN Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
Oxidoreductase Activity, Oxidizing Metal Ions, NAD Or NADP As Acceptor
[methionine Synthase] Reductase Activity
Flavin Adenine Dinucleotide Binding
NADP Binding
ATP Binding
Cob(I)yrinic Acid A,c-diamide Adenosyltransferase Activity
Biological Process
Sulfur Amino Acid Metabolic Process
DNA Methylation
Methionine Metabolic Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Xenobiotic Metabolic Process
Methionine Biosynthetic Process
Cobalamin Metabolic Process
Methylation
Cellular Nitrogen Compound Metabolic Process
Small Molecule Metabolic Process
Folic Acid Metabolic Process
Oxidation-reduction Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Cobalamin Metabolic Process
Cobalamin Biosynthetic Process
Small Molecule Metabolic Process
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Defective BTD causes biotidinase deficiency
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Sulfur amino acid metabolism
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective UGT1A4 causes hyperbilirubinemia
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Metabolic disorders of biological oxidation enzymes
Metabolism of amino acids and derivatives
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective AMN causes hereditary megaloblastic anemia 1
Defective UGT1A1 causes hyperbilirubinemia
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Biological oxidations
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GGT1 causes Glutathionuria (GLUTH)
Defects in cobalamin (B12) metabolism
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Defective GIF causes intrinsic factor deficiency
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MMAA causes methylmalonic aciduria type cblA
Defective CUBN causes hereditary megaloblastic anemia 1
Cobalamin (Cbl, vitamin B12) transport and metabolism
Phase II conjugation
Methylation
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in vitamin and cofactor metabolism
Metabolism of vitamins and cofactors
Defective GIF causes intrinsic factor deficiency
Defective CD320 causes methylmalonic aciduria
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MMAA causes methylmalonic aciduria type cblA
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective CUBN causes hereditary megaloblastic anemia 1
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective AMN causes hereditary megaloblastic anemia 1
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Drugs
Cyanocobalamin
L-Methionine
Hydroxocobalamin
Hydroxocobalamin
Diseases
GWAS
Capecitabine sensitivity (
22864933
)
HDL cholesterol (
18193043
20864672
19060906
20686565
)
Protein-Protein Interactions
2 interactors:
GMCL1
MMAB
2 interactors:
MTRR
SPERT
Entrez ID
4552
326625
HPRD ID
03979
07398
Ensembl ID
ENSG00000124275
ENSG00000139428
Uniprot IDs
Q9UBK8
Q96EY8
PDB IDs
2QTL
2QTZ
2IDX
Enriched GO Terms of Interacting Partners
?
Cobalamin Biosynthetic Process
Cobalamin Metabolic Process
Folic Acid Metabolic Process
Methionine Biosynthetic Process
Cobalamin Metabolic Process
Methionine Metabolic Process
Sulfur Amino Acid Biosynthetic Process
Sulfur Amino Acid Metabolic Process
Folic Acid-containing Compound Metabolic Process
Pteridine-containing Compound Metabolic Process
DNA Methylation
Tetrapyrrole Metabolic Process
Water-soluble Vitamin Metabolic Process
DNA Modification
Dicarboxylic Acid Metabolic Process
Vitamin Metabolic Process
Cellular Amino Acid Biosynthetic Process
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Response To Xenobiotic Stimulus
Regulation Of Gene Expression, Epigenetic
Cellular Modified Amino Acid Metabolic Process
Cellular Amide Metabolic Process
Alpha-amino Acid Metabolic Process
Cofactor Metabolic Process
Sulfur Compound Metabolic Process
Methylation
Cellular Amino Acid Metabolic Process
Tagcloud
?
aa
aas
african
american
ancestry
asian
associations
carbon
circle
comparisons
copyright
correcting
ea
eas
eleven
european
folate
metabolizing
modest
participated
polygenetic
polymorphisms
reserved
rights
shmt1
slc19a1
snps
tyms
Tagcloud (Difference)
?
aa
aas
african
american
ancestry
asian
associations
carbon
circle
comparisons
copyright
correcting
ea
eas
eleven
european
folate
metabolizing
modest
participated
polygenetic
polymorphisms
reserved
rights
shmt1
slc19a1
snps
tyms
Tagcloud (Intersection)
?