NUDT1 and TYW2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NUDT1	TYW2
Name		nudix hydrolase 1	tRNA wybutosine-synthesizing protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm
	Molecular Function	RNA Binding Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity DATP Diphosphatase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides SnoRNA Binding 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Metal Ion Binding ATP Diphosphatase Activity 2-hydroxy-ATP Hydrolase Activity 2-hydroxy-dATP Hydrolase Activity N6-methyl-(d)ATP Hydrolase Activity O6-methyl-dGTP Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Protein Binding TRNA Methyltransferase Activity Transferase Activity TRNA 4-demethylwyosine Alpha-amino-alpha-carboxypropyltransferase Activity
	Biological Process	Purine Nucleoside Catabolic Process DNA Repair Response To Oxidative Stress DNA Protection	TRNA Modification TRNA Processing TRNA Methylation Wybutosine Biosynthetic Process
Pathways		None	Synthesis of wybutosine at G37 of tRNA(Phe)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Dimensional psychopathology (Social) ( 29496196 ) Schizophrenia ( 22688191 23974872 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: CFTR FMNL3 SKP2 TYW2	3 interacting genes: LNX1 NUDT1 PRDM6
Entrez ID		4521	55039
HPRD ID		02634	07947
Ensembl ID		ENSG00000106268	ENSG00000183665
Uniprot IDs		P36639	Q53H54
PDB IDs		1IRY 3Q93 3WHW 3ZR0 3ZR1 4C9W 4C9X 4N1T 4N1U 5ANS 5ANT 5ANU 5ANV 5ANW 5FSI 5FSK 5FSL 5FSM 5FSN 5FSO 5GHI 5GHJ 5GHM 5GHN 5GHO 5GHP 5GHQ 5NGR 5NGS 5NGT 5NHY 5OTM 5WS7 6AA3 6AA4 6AA5 6EQ2 6EQ3 6EQ4 6EQ5 6EQ6 6EQ7 6F1X 6F20 6F22 6F23 6GLE 6GLF 6GLG 6GLH 6GLI 6GLJ 6GLK 6GLL 6GLM 6GLN 6GLO 6GLP 6GLQ 6GLR 6GLS 6GLT 6GLU 6GLV 6IJY 6ILI 6IMZ 6JVF 6JVG 6JVH 6JVI 6JVJ 6JVK 6JVL 6JVM 6JVN 6JVO 6JVP 6JVQ 6JVR 6JVS 6JVT 6QVO 6US2 6US3 6US4 7ESF 7N03 7N13 8A07 8A0S 8A0T 8A34 8A3A 8I18 8I19 8I1A 8I1C 8I1D 8I1E 8I1F 8I1G 8I1H 8I1I 8I1J 8I8S 8I8T	Not available
GO Terms Enriched among Interactors		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRNA 4-demethylwyosine Alpha-amino-alpha-carboxypropyltransferase Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Cellular Response To Cell-matrix Adhesion Transepithelial Water Transport Wybutosine Biosynthetic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization TRNA Methyltransferase Activity Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity GTPase Activating Protein Binding Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Positive Regulation Of Protein Polyubiquitination	2-hydroxy-dATP Hydrolase Activity 2-hydroxy-ATP Hydrolase Activity O6-methyl-dGTP Hydrolase Activity DATP Diphosphatase Activity N6-methyl-(d)ATP Hydrolase Activity 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity ATP Diphosphatase Activity Histone H4K20 Monomethyltransferase Activity Purine Nucleoside Catabolic Process DNA Protection 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Nucleobase-containing Small Molecule Catabolic Process Synapse Maturation SnoRNA Binding Negative Regulation Of Smooth Muscle Cell Differentiation Purine Nucleoside Metabolic Process Histone Methyltransferase Activity Nucleoside Metabolic Process Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Smooth Muscle Cell Differentiation Metal Ion Binding