TYW1B and TAS2R19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TYW1B	TAS2R19
Description		tRNA-yW synthesizing protein 1 homolog B	taste 2 receptor member 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding FMN Binding Lyase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding TRNA-4-demethylwyosine Synthase Activity	G Protein-coupled Receptor Activity Protein Binding Bitter Taste Receptor Activity
	Biological Process	TRNA Processing Wybutosine Biosynthetic Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases
GWAS		Triglyceride levels ( 28334899) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20686565 24097068) Waist circumference ( 28552196)
Interacting Genes		2 interacting genes: FOXP1 TAS2R19	7 interacting genes: LNPEP MMGT1 PGRMC2 PVR TMEM14B TMEM167B TYW1B
Entrez ID		441250	259294
HPRD ID		19608	18156
Ensembl ID		ENSG00000277149	ENSG00000212124
Uniprot IDs		Q6NUM6	P59542
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-21 Production Monocyte Activation Regulation Of Defense Response To Bacterium Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Osteoclast Development Negative Regulation Of Androgen Receptor Signaling Pathway Striatum Development Positive Regulation Of B Cell Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation T Follicular Helper Cell Differentiation Core Promoter Sequence-specific DNA Binding Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Bitter Taste Receptor Activity Regulation Of B Cell Apoptotic Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Tissue Growth Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Nuclear Androgen Receptor Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway T-helper Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Muscle Hypertrophy Response To Testosterone Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Organ Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy Sensory Perception Of Taste Negative Regulation Of Striated Muscle Cell Differentiation T Cell Differentiation Involved In Immune Response Osteoclast Differentiation CD4-positive, Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Regulation Of Heart Growth Macrophage Activation Alpha-beta T Cell Differentiation Forebrain Development Regulation Of Lymphocyte Apoptotic Process CD4-positive, Alpha-beta T Cell Activation Regulation Of Morphogenesis Of An Epithelium Myeloid Cell Development Negative Regulation Of Muscle Cell Differentiation Regulation Of Interleukin-12 Production	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Iron Ion Transport TRNA-4-demethylwyosine Synthase Activity Susceptibility To T Cell Mediated Cytotoxicity Cobalt Ion Transmembrane Transporter Activity Early Endosome Lumen Neuropeptide Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Susceptibility To Natural Killer Cell Mediated Cytotoxicity Heme Transmembrane Transporter Activity Heme Transport Constitutive Secretory Pathway Inorganic Cation Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Wybutosine Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence EMC Complex Cobalt Ion Transport
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