CARD17 and CARD16

Number of citations of the paper that reports this interaction (PMID 15383541)
19

Data Source:
HPRD (in vitro, in vivo)

		CARD17	CARD16
Gene Name		caspase recruitment domain family, member 17	caspase recruitment domain family, member 16
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity	Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process	Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CARD16 CARD18 CASP1	4 interactors: CARD17 CARD8 CASP1 RIPK2
Entrez ID		440068	114769
HPRD ID		17149	16740
Ensembl ID		ENSG00000255221	ENSG00000204397
Uniprot IDs		Q5XLA6	Q5EG05
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Mitochondrial Depolarization Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Interleukin-1 Alpha Secretion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Pyroptosis Positive Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Catalytic Activity Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Catalytic Activity Response To ATP Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Metabolic Process Membrane Hyperpolarization Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Interleukin-1 Beta Production Cellular Response To Mechanical Stimulus Defense Response Execution Phase Of Apoptosis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Autophagy Membrane Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Cytokine Production Positive Regulation Of Peptidase Activity	Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cytokine Production Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Cell Death Regulation Of Peptidase Activity Regulation Of Interleukin-1 Beta Production Regulation Of Cytokine Production Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Positive Regulation Of Peptidase Activity Apoptotic Process Programmed Cell Death Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Death Positive Regulation Of Protein Secretion Positive Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Protein Metabolic Process Protein Processing Response To Interleukin-12 Positive Regulation Of Proteolysis Positive Regulation Of Immature T Cell Proliferation
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