KLK12 and SRP54

		KLK12	SRP54
Description		kallikrein related peptidase 12	signal recognition particle 54
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck Signal Recognition Particle Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding Hydrolase Activity GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding
	Biological Process	Proteolysis Protein Maturation	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER
Pathways		Formation of the cornified envelope	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes			4 interacting genes: CEBPA OGT RNPS1 SRP19
Entrez ID		43849	6729
HPRD ID		05705	05330
Ensembl ID		ENSG00000186474	ENSG00000100883
Uniprot IDs		A0A024R4M4 B9EGA9 Q49AM7 Q9UKR0	G3V480 P61011
PDB IDs			1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32 7NFX 7QWQ
Enriched GO Terms of Interacting Partners?		Signal Recognition Particle Exocrine Pancreas Development Endoplasmic Reticulum Signal Peptide Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation 7S RNA Binding SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Intracellular Protein Transmembrane Transport Granulocyte Differentiation Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Ribonucleoprotein Complex Binding Neutrophil Chemotaxis Protein Transmembrane Transport Protein Targeting To Membrane GDP Binding Granulocyte Chemotaxis Neutrophil Migration Granulocyte Migration Myeloid Leukocyte Migration Leukocyte Chemotaxis Myeloid Leukocyte Differentiation Cell Chemotaxis Establishment Of Protein Localization To Membrane Protein Targeting Leukocyte Migration Myeloid Cell Differentiation Gland Development GTPase Activity Establishment Of Protein Localization To Organelle Chemotaxis Leukocyte Differentiation Locomotion GTP Binding Ribonucleoprotein Complex Nuclear Speck
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