MAP3K1 and YWHAE

Number of citations of the paper that reports this interaction (PMID 9452471)
16

Data Source:
BioGRID (pull down)

		MAP3K1	YWHAE
Gene Name		mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Mitochondrion Cytosol Kinesin Complex Focal Adhesion Membrane Axon Cytoplasmic Vesicle Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding JUN Kinase Kinase Activity Protein Kinase Binding	Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Histone Deacetylase Binding Ion Channel Binding Poly(A) RNA Binding Protein Heterodimerization Activity Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Activation Of MAPKK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Epithelial Cell Morphogenesis Protein Phosphorylation Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of JUN Kinase Activity Apoptotic Mitochondrial Changes Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Wound Healing Innate Immune Response Eyelid Development In Camera-type Eye Cellular Response To Mechanical Stimulus	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Neuron Migration Regulation Of Heart Rate By Hormone Protein Targeting Apoptotic Process Organelle Organization Viral Process Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System	HSF1 activation Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane G2/M Transition Activation of BH3-only proteins Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Programmed Cell Death Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Assembly of the primary cilium Cellular response to heat stress Regulation of HSF1-mediated heat shock response Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Signaling by Hippo Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation NADE modulates death signalling Mitotic G2-G2/M phases
Drugs
Diseases
GWAS		Breast cancer ( 17529967 23535729 20453838 19330030) Triglycerides ( 20686565) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		30 interactors: ACTN1 ARHGAP4 BRCA1 CHUK CRTC1 DCAF7 DTX1 GRB2 GSK3B IKBKB JUN MAP2K4 MAP2K7 MAPK1 MAPK3 MAPK8 MAPK9 NFKBIA NR4A1 PAK1 RAF1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L6 UBE2W YWHAE	107 interactors: ABL1 ACD AKAP13 ANKHD1-EIF4EBP3 ARHGEF2 ARHGEF28 ATXN1 BAD BCR CALM1 CAP2 CASP3 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP95 CGNL1 CHAF1A COX2 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GTF2B HDAC4 HDAC5 HIVEP2 HSF1 IGF1R IL7R ING1 IRS1 IRS2 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KRT18 LRMP MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MDM4 MSL2 MST1R MYH10 NCOR2 NDEL1 NGFRAP1 PAPOLA PNLIP POT1 PRKCG RAF1 RAP1GAP2 RASAL3 RASGRF1 REM1 RGS3 RIN1 RPGR SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SNCA SORBS2 SRC SSFA2 SYN2 TAF7 TAZ TBC1D3F TBP TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF839
Entrez ID		4214	7531
HPRD ID		19599	05457
Ensembl ID		ENSG00000095015	ENSG00000108953
Uniprot IDs		Q13233	P62258
PDB IDs			2BR9 3UAL 3UBW
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Fc Receptor Signaling Pathway Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response Regulation Of Immune System Process Response To Abiotic Stimulus Response To Organic Substance Defense Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Response To Stress Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Stress Immune System Process Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor System Development Neurotrophin TRK Receptor Signaling Pathway Developmental Process Neurotrophin Signaling Pathway Negative Regulation Of Phosphorylation Response To Organic Substance Anatomical Structure Development Multicellular Organismal Development Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Programmed Cell Death Regulation Of Cellular Component Organization Cell Death Death Cellular Response To Organonitrogen Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Difference) ?		5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Intersection) ?