MARK1 and KCNK2

		MARK1	KCNK2
Description		microtubule affinity regulating kinase 1	potassium two pore domain channel subfamily K member 2
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Dendrite Cell Projection Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Axon Dendrite Node Of Ranvier Sarcolemma Cell Projection Neuronal Cell Body Axon Terminus Calyx Of Held Synapse Postsynaptic Membrane Astrocyte Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphatidylserine Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity	Voltage-gated Potassium Channel Activity Potassium Channel Activity Outward Rectifier Potassium Channel Activity Potassium Channel Inhibitor Activity Ligand-gated Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Mechanosensitive Potassium Channel Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization Regulation Of Postsynapse Assembly	Cardiac Ventricle Development Monoatomic Ion Transport Potassium Ion Transport G Protein-coupled Receptor Signaling Pathway Memory Response To Mechanical Stimulus Glutamate Secretion Neuronal Action Potential Regulation Of Synaptic Transmission, GABAergic Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Response To Axon Injury Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development Chemical Synaptic Transmission, Postsynaptic Positive Regulation Of Cellular Response To Hypoxia Chloride Transmembrane Transport Cellular Response To Arachidonate Negative Regulation Of DNA Biosynthetic Process
Pathways			TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
Drugs		Fostamatinib	Dofetilide Dronedarone
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Cortical thickness (MOSTest) ( 32665545) Lung function (FVC) ( 30061609) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		11 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B TFAP2A YAF2
Entrez ID		4139	3776
HPRD ID		07353	04450
Ensembl ID		ENSG00000116141	ENSG00000082482
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	O95069 Q6ZW95 U3N6F0 U3N834
PDB IDs		2HAK 3OSE 6C9D	4TWK
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule-based Process Positive Regulation Of Vesicle Transport Along Microtubule Main Axon Central Nervous System Neuron Development Regulation Of Microtubule-based Movement Neuronal Cell Body Neuron Development Tubulin Binding Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Growth Embryonic Limb Morphogenesis Atrial Septum Morphogenesis Limb Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Stress-activated MAPK Cascade Generation Of Neurons Microtubule Polymerization Negative Regulation Of Developmental Process Regulation Of Growth Regulation Of Axonogenesis Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Ventricular Septum Morphogenesis Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Skeletal System Development Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Negative Regulation Of Cell Population Proliferation Axon Negative Regulation Of Cell Growth Regulation Of Cell Growth Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Organization Apical Distal Dendrite Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Microtubule Associated Complex Microtubule Polymerization Or Depolymerization Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Optic Cup Structural Organization	Tau-protein Kinase Activity Regulation Of Postsynapse Assembly Phosphatidylserine Binding Negative Regulation Of Epithelial To Mesenchymal Transition Establishment Of Mitochondrion Localization Tau Protein Binding Phosphatidic Acid Binding Mitochondrion Localization Phosphatidylinositol-4,5-bisphosphate Binding
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