MARK1 and CCR6

		MARK1	CCR6
Description		microtubule affinity regulating kinase 1	C-C motif chemokine receptor 6
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Dendrite Cell Projection Postsynapse Glutamatergic Synapse	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphatidylserine Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization Regulation Of Postsynapse Assembly	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 18587394 23850713 21102463 20570966) Graves' disease ( 22922229) Inflammatory bowel disease ( 23128233 27569725 28067908) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 32723749 24390342 23143596 20453841) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 27723757 20526339)
Interacting Genes		11 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B TFAP2A YAF2	5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1
Entrez ID		4139	1235
HPRD ID		07353	03498
Ensembl ID		ENSG00000116141	ENSG00000112486
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	P51684
PDB IDs		2HAK 3OSE 6C9D	6WWZ
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule-based Process Positive Regulation Of Vesicle Transport Along Microtubule Main Axon Central Nervous System Neuron Development Regulation Of Microtubule-based Movement Neuronal Cell Body Neuron Development Tubulin Binding Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Growth Embryonic Limb Morphogenesis Atrial Septum Morphogenesis Limb Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Stress-activated MAPK Cascade Generation Of Neurons Microtubule Polymerization Negative Regulation Of Developmental Process Regulation Of Growth Regulation Of Axonogenesis Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Ventricular Septum Morphogenesis Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Skeletal System Development Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Negative Regulation Of Cell Population Proliferation Axon Negative Regulation Of Cell Growth Regulation Of Cell Growth Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Organization Apical Distal Dendrite Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Microtubule Associated Complex Microtubule Polymerization Or Depolymerization Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Optic Cup Structural Organization	CCR6 Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Humoral Immune Response Defense Response To Gram-negative Bacterium Locomotion Defense Response To Bacterium Chemotaxis Golgi Lumen Defense Response To Other Organism Defense Response To Gram-positive Bacterium Defense Response To Symbiont Killing Of Cells Of Another Organism Response To Bacterium Chemoattractant Activity Cell Killing Cell Chemotaxis Response To Other Organism Positive Chemotaxis Immune Response Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Response To External Biotic Stimulus Defense Response Phosphatidylinositol-4,5-bisphosphate Binding Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Regulation Of Response To DNA Integrity Checkpoint Signaling Extracellular Space Cell Migration Flavin-dependent Sulfhydryl Oxidase Activity Thymocyte Migration Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Nuclear Speck Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse L-lysine Catabolic Process Negative Regulation Of Translational Elongation Cell Motility Thiol Oxidase Activity Splicing Factor Binding Immune System Process Lysine Catabolic Process Negative Regulation Of Centriole Replication Calcium-mediated Signaling Positive Regulation Of Gene Expression
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