MIR16-1 and ZNF346

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR16-1	ZNF346
Description		microRNA 16-1	zinc finger protein 346
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Protein Binding Zinc Ion Binding Enzyme Binding MiRNA Binding Metal Ion Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Angiogenesis MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Translation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Placenta Blood Vessel Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Mesenchymal Stem Cell Proliferation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Connective Tissue Replacement Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of Glucosylceramide Catabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Height ( 28552196 31562340) Type 2 diabetes ( 30718926) Uterine fibroids ( 30194396 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		71 interacting genes: APOBEC3B C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LIN28A LRPPRC MATR3 MSI2 NONO NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 RARS1 RBFOX2 RBM14 RBM47 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	67 interacting genes: ADARB1 ANKHD1 EIF2AK2 ILF3 LNX1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR141 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR214 MIR221 MIR222 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I NKRF RNF10 RNF8 STRBP TARBP2 XPO5
Entrez ID		406950	23567
HPRD ID			05606
Ensembl ID		ENSG00000208006	ENSG00000113761
Uniprot IDs			B7Z4J8 B7Z4N4 D6RJ07 Q9UL40
PDB IDs			2MKD 2MKN
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Splicing RNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleoplasm Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Translation MRNA Stabilization MRNA 3'-UTR Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Positive Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Positive Regulation Of Cytoplasmic Translation MiRNA Binding Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Translation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process	MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Stability Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Migration Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cytokine Production
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