CELF2 and MIR19B1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		CELF2	MIR19B1
Description		CUGBP Elav-like family member 2	microRNA 19b-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Flemming Body Ribonucleoprotein Complex	Extracellular Space RISC Complex Perinuclear Region Of Cytoplasm Blood Microparticle Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Pre-mRNA Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition RNA Processing MRNA Processing Regulation Of Heart Contraction	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Fibroblast Migration Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Cholesterol Homeostasis Negative Regulation Of Coagulation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Fate Commitment Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Bacterial Lipopeptide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Apoptotic Process Involved In Development Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Activity variability during wake ( 33075057) Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Allergic rhinitis ( 30013184) Asthma ( 29273806 34103634) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 33549134) Body size at age 10 ( 32376654) Breastfeeding duration ( 25475840) Chronic kidney disease ( 31015462) Cognitive function in longevity ( 33607172) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 33627673) Glycemic traits (pleiotropy) ( 31021400) Liver enzyme levels (alanine transaminase) ( 24124411) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean platelet volume ( 32888494) Motion sickness ( 25628336) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Response to lamotrigine in genetic generalized epilepsy ( 32308125) Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		23 interacting genes: A1CF APOBEC1 APP CEBPA ELAVL1 MIR140 MIR155 MIR18B MIR199A1 MIR19A MIR19B1 MIR205 MIR21 MIR29C MIR34B MIR363 MIR7-1 MIR9-2 MIRLET7I PCBP1 PTGS2 RNF10 TRAF3	103 interacting genes: AIMP1 AIMP2 APOBEC3B AQR C1QBP CELF1 CELF2 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBBP6 RBFOX2 RBM12B RBM14 RBM4 RBMS2 RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 WDR33 WWP1 WWP2 YBX1 YBX2 YBX3 ZNF346 ZNF385A
Entrez ID		10659	406980
HPRD ID		03964
Ensembl ID		ENSG00000048740	ENSG00000284375
Uniprot IDs		A0A0J9YX66 A0A0J9YXJ0 A0A1B0GU44 A0A1B0GUN8 B4DDE7 B4DIB6 B4DT00 B4DZ01 E9PC62 O95319
PDB IDs		2MY7 2MY8 4LJM 4LMZ 4TLQ 5M8I
Enriched GO Terms of Interacting Partners?		Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression RISC Complex MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Developmental Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Extracellular Vesicle Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cell Population Proliferation RNA Destabilization Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of RNA Stability Regulation Of Developmental Process Regulation Of Cell Population Proliferation	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA 3'-UTR Binding Spliceosomal Complex Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule MiRNA Binding Negative Regulation Of MRNA Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity RNA 3'-end Processing TRNA Aminoacylation Negative Regulation Of Translation Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Metabolic Process Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of RNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process Regulation Of MRNA Stability MRNA Stabilization Negative Regulation Of Macromolecule Metabolic Process Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation
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