KRTAP5-4 and BAG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP5-4	BAG5
Description		keratin associated protein 5-4	BAG cochaperone 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Inclusion Body Junctional Membrane Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process		Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Protein Refolding Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Keratinization	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Broad depression or schizophrenia ( 30626913) Depression ( 29700475) Schizophrenia ( 25056061)
Interacting Genes		62 interacting genes: ADAMTSL4 BAG5 CATSPER1 CRCT1 CREB5 CRY2 CYSRT1 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NOTCH2NLA NUFIP2 OTX1 PLEKHF2 POU4F2 RGS17 RGS20 SMCP UBE2I VASN	19 interacting genes: BANP CDCA7L CIRBP CREBBP DES EFEMP1 FAM118B GOLGA6A KASH5 KRTAP5-4 LRRK1 PINK1 PRKN SNCA STUB1 THAP1 TP53 TRIM27 VCP
Entrez ID		387267	9529
HPRD ID		12396	04862
Ensembl ID		ENSG00000241598	ENSG00000166170
Uniprot IDs		A8MUN0 Q6L8H1	A0A024R6M6 Q9UL15
PDB IDs			2D9D 3A8Y
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding	Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of ATP Biosynthetic Process Identical Protein Binding Dopamine Transport Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitophagy Cellular Response To Hydrogen Sulfide Regulation Of ATP Biosynthetic Process Regulation Of Dopamine Secretion Regulation Of Oxidative Phosphorylation Cellular Response To Topologically Incorrect Protein Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Protein-containing Complex Assembly Monoamine Transport Regulation Of Protein Stability Regulation Of Autophagy Response To Hydrogen Sulfide Negative Regulation Of Autophagy Protein Stabilization Negative Regulation Of Mitochondrial Fission Positive Regulation Of ATP Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Synaptic Vesicle Transport Regulation Of Catecholamine Secretion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein-containing Complex Assembly Lewy Body Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Regulation Of Cellular Respiration Regulation Of Release Of Cytochrome C From Mitochondria Tau Protein Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Hsp70 Protein Binding Autophagy Ubiquitin Protein Ligase Binding Positive Regulation Of Organelle Organization Macroautophagy Inclusion Body Assembly Positive Regulation Of Small Molecule Metabolic Process Mitophagy Fibrillar Center Protein Destabilization
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