KCTD4 and TNS4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		KCTD4	TNS4
Description		potassium channel tetramerization domain containing 4	tensin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction
	Molecular Function	Protein Binding Identical Protein Binding	Actin Binding Protein Binding
	Biological Process	Protein Homooligomerization	Intracellular Protein Localization
Pathways			MET interacts with TNS proteins
Drugs
Diseases
GWAS			Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		6 interacting genes: DAXX EFHC1 FER FXR2 NTAQ1 TNS4	23 interacting genes: AR CARD9 CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1
Entrez ID		386618	84951
HPRD ID		13767	12223
Ensembl ID		ENSG00000180332	ENSG00000131746
Uniprot IDs		Q8WVF5	Q6PJP3 Q8IZW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Cell-cell Junction Disassembly Adherens Junction Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Kit Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Sodium Arsenite Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Mast Cell Activation Involved In Immune Response Tyrosine Phosphorylation Of STAT Protein Extracellular Matrix-cell Signaling Response To Sodium Arsenite Cellular Response To Salt	Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process ErbB-3 Class Receptor Binding Positive Regulation Of Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Eyelid Development In Camera-type Eye Receptor Complex Morphogenesis Of An Epithelial Fold Kinase Activity Negative Regulation Of Programmed Cell Death ATPase Binding Protein Tyrosine Kinase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Viral Transcription Mammary Gland Alveolus Development Suppression Of Viral Release By Host Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Multicellular Organismal Process
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