KIR3DL2 and HLA-A

Number of citations of the paper that reports this interaction (PMID 8760804)
54

Data Source:
HPRD (in vitro, in vivo)

		KIR3DL2	HLA-A
Gene Name		killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	major histocompatibility complex, class I, A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function		Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding Poly(A) RNA Binding TAP Binding
	Biological Process	Cellular Defense Response Regulation Of Immune Response	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Memory T Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Adverse response to carbamapezine ( 21149285) Beta-2 microglubulin plasma levels ( 23417110) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Nasopharyngeal carcinoma ( 19664746 20512145) Vitiligo ( 20410501)
Protein-Protein Interactions		1 interactors: HLA-A	25 interactors: APLP2 B2M BCAP31 CALR CANX CD8A DEK DERL1 ERBB2 KIR3DL2 LILRB1 LILRB2 MAGEA1 MAGEA4 MEOX2 PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17
Entrez ID		3812	3105
HPRD ID		10384	00826
Ensembl ID		ENSG00000240403	ENSG00000206503
Uniprot IDs		P43630 Q8NHI6 Q8NHK6	B1PKY1 B2R7U3 P04439 P30443 Q5SUL5
PDB IDs			1W72 2XPG 3BO8 3RL1 3RL2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Memory T Cell Activation Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Detection Of Biotic Stimulus Negative Regulation Of Innate Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Response To Interferon-gamma Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Response To Bacterium	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Immune System Process Antigen Processing And Presentation Of Peptide Antigen Defense Response Neurotrophin TRK Receptor Signaling Pathway Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Communication Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune Response Regulation Of Immune System Process Signal Transduction Homeostatic Process Cellular Response To Organic Substance Response To Stress Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemical Homeostasis Regulation Of Immune Response Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Kinase Activity Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Stimulus Regulation Of Kinase Activity Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Viral Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-inhibiting Signal Transduction Response To Growth Factor Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Dendritic Cell Differentiation Negative Regulation Of T Cell Proliferation Protein Transport
Tagcloud ?		attracted biomarker candidates chip cnot1 coincided displaying disturbance edg1 epigenome h3k4me3 hypomethylation immunological immunoprecipitation inverse links medip methylation microarray mononuclear nephrology pltp q qpcr qrt tcf3 uremia validate variations
Tagcloud (Difference) ?		attracted biomarker candidates chip cnot1 coincided displaying disturbance edg1 epigenome h3k4me3 hypomethylation immunological immunoprecipitation inverse links medip methylation microarray mononuclear nephrology pltp q qpcr qrt tcf3 uremia validate variations
Tagcloud (Intersection) ?