KCNJ5 and KCNJ15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNJ5	KCNJ15
Description		potassium inwardly rectifying channel subfamily J member 5	potassium inwardly rectifying channel subfamily J member 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Inward Rectifier Potassium Channel Complex I(KACh) Inward Rectifier Potassium Channel Complex	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Potassium Ion Transport Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ethanol Ifenprodil	Ritodrine Yohimbine Butamben
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive error ( 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte count ( 32888494) Non-response to antidepressants and depression ( 27622933) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: ADRB2 KCNJ15 KCNJ3	6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1
Entrez ID		3762	3772
HPRD ID		09010	03659
Ensembl ID		ENSG00000120457	ENSG00000157551
Uniprot IDs		A0A5J6E2W8 P48544	Q99712
PDB IDs
Enriched GO Terms of Interacting Partners?		Inward Rectifier Potassium Channel Activity Regulation Of Monoatomic Ion Transport Potassium Ion Import Across Plasma Membrane Import Into Cell Inorganic Cation Import Across Plasma Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Beta2-adrenergic Receptor Activity I(KACh) Inward Rectifier Potassium Channel Complex Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Transport Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway G-protein Activated Inward Rectifier Potassium Channel Activity Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Inward Rectifier Potassium Channel Complex Positive Regulation Of Autophagosome Maturation Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Regulation Of Membrane Potential Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Negative Regulation Of Multicellular Organism Growth Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of System Process Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport	Regulation Of Monoatomic Ion Transport Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Inward Rectifier Potassium Channel Activity Membrane Repolarization Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Ion Channel Complex Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Cardiac Conduction Potassium Ion Transport Regulation Of Heart Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Blood Circulation Inorganic Cation Import Across Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Action Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Import Across Plasma Membrane Positive Regulation Of Potassium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Kinesin Binding Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Ammon Gyrus Development Dendrite Morphogenesis Monoatomic Ion Transport Regulation Of System Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Potassium Ion Transmembrane Transport Vestibular Nucleus Development Regulation Of Monoatomic Cation Transmembrane Transport Relaxation Of Skeletal Muscle
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