SIMC1 and DNAJB11

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		SIMC1	DNAJB11
Description		SUMO interacting motifs containing 1	DnaJ heat shock protein family (Hsp40) member B11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PML Body Sarcomere	Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Chaperone Complex Protein Folding Chaperone Complex
	Molecular Function	Protein Binding Peptidase Inhibitor Activity SUMO Polymer Binding	Signaling Receptor Binding Protein Binding Unfolded Protein Binding Misfolded Protein Binding
	Biological Process		Protein Folding MRNA Modification Positive Regulation Of ATP-dependent Activity Negative Regulation Of Neurogenesis Protein Maturation
Pathways			XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: CSNK2B DNAJB11 PLK1 SUMO2 TUBA4A YWHAG YWHAZ	24 interacting genes: ANKZF1 APOBEC1 BAG6 CEP70 COL6A1 CRMP1 DDAH2 DNAJC13 DRAP1 EIF3D EZH2 FAF1 GRB2 HSPA1A HTN3 PAXIP1 PTN SIMC1 SNX5 SPRED1 SUMO4 UBQLN4 UBR1 ZZZ3
Entrez ID		375484	51726
HPRD ID		13486	07485
Ensembl ID		ENSG00000170085	ENSG00000090520
Uniprot IDs		B4DRM7 Q8NDZ2	Q9UBS4
PDB IDs		7T5P
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Protein Domain Specific Binding Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Hippocampal Mossy Fiber To CA3 Synapse Protein Sequestering Activity Cellular Response To Glucose Starvation Phosphorylation Protein Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Stability Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TOR Signaling Protein Kinase Binding Negative Regulation Of TOR Signaling PML Body Synaptonemal Complex Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Golgi Inheritance Regulation Of TORC1 Signaling Synaptic Target Recognition Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Kinase C Inhibitor Activity Mitotic Cell Cycle Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus Release From Viral Latency Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Protein Modification By Small Protein Conjugation Golgi Reassembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Cellular Response To Starvation Vesicle Phosphoserine Residue Binding Macromolecule Metabolic Process Positive Regulation Of Proteolysis	Cellular Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Positive Regulation Of Dendrite Development Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Misfolded Protein Binding Biomineral Tissue Development Response To Endoplasmic Reticulum Stress ERAD Pathway
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