Wiki-Pi
About
Search
People
Updates
Search
AR and HDAC3
Number of citations of the paper that reports this interaction (PubMedID
33640491
)
71
Data Source:
BioGRID
(pull down, proximity labelling technology, affinity chromatography technology)
AR
HDAC3
Description
androgen receptor
histone deacetylase 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Speck
Protein-containing Complex
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II General Transcription Initiation Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Steroid Binding
Androgen Binding
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Lipid Binding
Enzyme Binding
Estrogen Response Element Binding
Sequence-specific DNA Binding
Metal Ion Binding
ATPase Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
POU Domain Binding
Molecular Condensate Scaffold Activity
Sequence-specific Double-stranded DNA Binding
Transcription Corepressor Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Deacetylase Activity
Enzyme Binding
Cyclin Binding
Chromatin DNA Binding
Protein Lysine Deacetylase Activity
Histone Deacetylase Binding
GTPase Binding
NF-kappaB Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein De-2-hydroxyisobutyrylase Activity
Protein Lysine Delactylase Activity
Ubiquitin-specific Protease Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
In Utero Embryonic Development
Regulation Of Systemic Arterial Blood Pressure
Epithelial Cell Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Signal Transduction
Cell-cell Signaling
Spermatogenesis
Single Fertilization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Fertilization
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Male Somatic Sex Determination
Estrogen Receptor Signaling Pathway
Androgen Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Leydig Cell Differentiation
Response To Testosterone
Multicellular Organism Growth
Positive Regulation Of MAPK Cascade
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Differentiation
Positive Regulation Of Integrin Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Insulin-like Growth Factor Receptor Signaling Pathway
Reproductive Structure Development
Regulation Of Developmental Growth
Animal Organ Formation
Male Genitalia Morphogenesis
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Prostate Induction
Morphogenesis Of An Epithelial Fold
Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
Regulation Of Prostatic Bud Formation
Prostate Gland Growth
Prostate Gland Epithelium Morphogenesis
Epithelial Cell Differentiation Involved In Prostate Gland Development
Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Mammary Gland Alveolus Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Reproductive System Development
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Testosterone Stimulus
Seminiferous Tubule Development
Membraneless Organelle Assembly
Positive Regulation Of MiRNA Transcription
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
In Utero Embryonic Development
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Transcription By RNA Polymerase II
Protein Deacetylation
Regulation Of Mitotic Cell Cycle
Epidermis Development
Response To Xenobiotic Stimulus
Gene Expression
Negative Regulation Of Myotube Differentiation
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Negative Regulation Of Interleukin-1 Production
Negative Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Protein Modification Process
Regulation Of Multicellular Organism Growth
Epigenetic Regulation Of Gene Expression
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Protein Export From Nucleus
Rhythmic Process
Spindle Assembly
Random Inactivation Of X Chromosome
Neural Precursor Cell Proliferation
Establishment Of Skin Barrier
Cellular Response To Mechanical Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Fluid Shear Stress
Response To Dexamethasone
Negative Regulation Of Ferroptosis
Positive Regulation Of Cold-induced Thermogenesis
DNA Repair-dependent Chromatin Remodeling
Positive Regulation Of Ferroptosis
Cornified Envelope Assembly
Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
RUNX2 regulates osteoblast differentiation
RUNX2 regulates osteoblast differentiation
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by PPARalpha
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
STAT3 nuclear events downstream of ALK signaling
Cytoprotection by HMOX1
Heme signaling
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diethylstilbestrol
Levonorgestrel
Progesterone
Spironolactone
Flutamide
Oxandrolone
Fluphenazine
Testosterone
Mitotane
Estrone
Nilutamide
Tamoxifen
Norethisterone
Drostanolone
Norgestimate
Nandrolone phenpropionate
Ketoconazole
Acetophenazine
Bicalutamide
Fluoxymesterone
Drospirenone
Danazol
Testosterone propionate
Oxybenzone
1-Testosterone
Boldenone
Calusterone
Periciazine
Prasterone
Flufenamic acid
Stanolone
(R)-Bicalutamide
Metribolone
(3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
Cyproterone acetate
LGD2941
Dimethylcurcumin
Oxymetholone
Methyltestosterone
Norelgestromin
Stanozolol
Tetrahydrogestrinone
(2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
BMS-564929
S-23
4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
(2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
Andarine
(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
LGD-2226
3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
Triclosan
Nandrolone decanoate
Ulipristal
Enzalutamide
Eugenol
Dienogest
Norethynodrel
Norgestrel
Homosalate
Enzacamene
Luprostiol
Mibolerone
Phenothiazine
Gestrinone
Apalutamide
Clascoterone
Darolutamide
Esculin
Ligandrol
Testosterone cypionate
Testosterone enanthate
Testosterone undecanoate
Stanolone acetate
Segesterone acetate
Boldenone undecylenate
Echinacoside
Ketodarolutamide
Valproic acid
Decitabine
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Phenylbutyric acid
Mocetinostat
Entinostat
Abexinostat
Givinostat
Pyroxamide
Diseases
Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
Prostate cancer
46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS
Balding (
26926045
)
Estradiol levels (
34255042
)
Excessive daytime sleepiness (
27992416
)
Fasting insulin (
34059833
)
LDL cholesterol (
19060910
)
Male-pattern baldness (
18849991
22032556
22693459
27182965
28196072
29146897
)
Prostate cancer (
21743467
)
Refractive error (
32231278
)
Interacting Genes
268 interacting genes:
ABL1
ABL2
ACTB
AHR
AKT1
APOL2
APPBP2
ARID5A
ATF2
BAG1
BLK
BLNK
BRCA1
BTK
CACUL1
CALM1
CALR
CASP1
CASP3
CASP7
CASP8
CAV1
CCAR2
CCND1
CCNE1
CCNH
CDC25A
CDC25B
CDC37
CDK1
CDK6
CDK7
CDK9
CEBPA
CEBPB
CHD8
COX5B
CREBBP
CRK
CTDSP2
CTNNB1
CUL4B
DAP3
DAXX
DCAF6
DCC
DDB2
DDC
DENND5A
EED
EFCAB6
EGFR
ELF3
EP300
ERCC2
ERCC3
ESR1
ETV5
EZH2
FES
FGR
FHL2
FLNA
FOXA1
FOXG1
FOXO1
GADD45GIP1
GAK
GAPDH
GLI2
GRAP2
GRB2
GRB7
GRIP1
GSK3B
GSN
GTF2F1
GTF2F2
GTF2H1
GTF2H2
GTF2H3
HCK
HDAC1
HDAC3
HDAC4
HIF1A
HIPK3
HMGB1
HMGB2
HOTAIR
HSH2D
HSP90AA1
IARS1
IDE
IFI16
IL6ST
INPPL1
JMJD1C
JUN
KAT2B
KAT5
KAT7
KDM1A
KIF15
KIF1A
KIFAP3
KLK2
LCK
LCOR
LYN
MAGEA11
MAPK1
MATK
MDM2
MDN1
MED1
MED12L
MED14
MED24
MLH3
MYBBP1A
MYLIP
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NDE1
NELFCD
NFKB1
NISCH
NLRP10
NONO
NR0B1
NR0B2
NR2C1
NR2C2
NR3C1
NR3C2
NR5A1
NRIP1
NSD1
NSD2
PA2G4
PAK6
PELP1
PGK1
PIAS1
PIAS2
PIAS3
PIAS4
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PNRC1
PNRC2
POU2F1
POU2F2
POU5F1
PRKG1
PRMT1
PRPF6
PSMC3IP
PTEN
PTK6
PTPN11
PXN
RAC3
RACK1
RAD54L2
RAD9A
RAF1
RAN
RANBP9
RASA1
RB1
RBAK
RCHY1
REL
RELA
REPS2
RNASEL
RNF14
RNF4
RNF6
RUNX1
RUNX2
SART3
SENP2
SFPQ
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3YL1
SHB
SHC1
SHC3
SHC4
SHE
SIRT1
SLC25A4
SMAD1
SMAD3
SMAD4
SMARCA2
SMARCA4
SMARCD1
SMARCE1
SNW1
SOCS3
SOCS6
SP1
SPDEF
SPOP
SRC
SREBF1
SRY
STAP1
STAT3
STUB1
SUMO1
SUV39H2
SVIL
SYK
TADA3
TAF1
TBP
TCF20
TCF4
TCF7L2
TDG
TGFB1I1
TGIF1
TLE5
TMF1
TNK2
TNS1
TNS4
TPD52
TRAF4
TRIM24
TRIP4
TSG101
TXNDC5
UBE2I
UBE3A
USP10
USP2
UXT
VAV1
VAV2
VAV3
VCP
WIPI1
XRCC5
XRCC6
YES1
YWHAQ
ZBTB1
ZBTB32
ZMIZ1
ZMIZ2
ZNF451
103 interacting genes:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRIP1
BRMS1
CBFA2T3
CCN5
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
CUL4B
DAXX
DHX30
EED
ELL
EP300
ESR1
EWSR1
GATA1
GATA2
GATA3
GCM1
GPS2
GTF2I
GTF2IRD1
H2AC1
H2BC1
H3C1
H4C1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1A
HIF1AN
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
XPO1
YY1
ZBTB16
Entrez ID
367
8841
HPRD ID
02437
08950
Ensembl ID
ENSG00000169083
ENSG00000171720
Uniprot IDs
A0A087WUX9
F1D8N5
G4VV16
P10275
Q9NUA2
O15379
PDB IDs
1E3G
1GS4
1T5Z
1T63
1T65
1XJ7
1XOW
1XQ3
1Z95
2AM9
2AMA
2AMB
2AO6
2AX6
2AX7
2AX8
2AX9
2AXA
2HVC
2OZ7
2PIO
2PIP
2PIQ
2PIR
2PIT
2PIU
2PIV
2PIW
2PIX
2PKL
2PNU
2Q7I
2Q7J
2Q7K
2Q7L
2YHD
2YLO
2YLP
2YLQ
2Z4J
3B5R
3B65
3B66
3B67
3B68
3BTR
3L3X
3L3Z
3RLJ
3RLL
3V49
3V4A
3ZQT
4HLW
4K7A
4OEA
4OED
4OEY
4OEZ
4OFR
4OFU
4OGH
4OH5
4OH6
4OHA
4OIL
4OIU
4OJ9
4OJB
4OK1
4OKB
4OKT
4OKW
4OKX
4OLM
4QL8
5CJ6
5JJM
5T8E
5T8J
5V8Q
5VO4
7ZTX
7ZTZ
7ZU1
7ZU2
8E1A
8FGY
8FGZ
8FH0
8FH1
8FH2
8RM6
8RM7
4A69
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Regulation Of Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Phosphotyrosine Residue Binding
Chromatin
Intracellular Signal Transduction
Nuclear Receptor Binding
Chromatin Binding
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway
Enzyme Binding
Regulation Of Developmental Process
Macromolecule Metabolic Process
Transcription Coactivator Activity
Cellular Response To Stress
Cell Differentiation
Cytosol
Regulation Of Cell Differentiation
Cellular Developmental Process
Regulation Of Signal Transduction
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Histone Deacetylase Binding
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromatin
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of RNA Metabolic Process
DNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Cis-regulatory Region Binding
DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Cell Differentiation
Transcription Repressor Complex
Transcription Regulator Complex
DNA-binding Transcription Factor Binding
Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of MiRNA Transcription
Chromatin Organization
Transcription Coactivator Binding
Regulation Of MiRNA Metabolic Process
Regulation Of Developmental Process
Histone Deacetylase Complex
DNA-binding Transcription Factor Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?