IDE and SLC28A2

		IDE	SLC28A2
Description		insulin degrading enzyme	solute carrier family 28 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome	Plasma Membrane Vesicle Membrane Membrane Apicolateral Plasma Membrane Coated Vesicle Brush Border Membrane
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Virus Receptor Activity Catalytic Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Peptide Hormone Binding Beta-endorphin Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Metal Ion Binding	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Nucleoside:sodium Symporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Pyrimidine- And Adenosine-specific:sodium Symporter Activity Azole Transmembrane Transporter Activity
	Biological Process	Proteolysis Insulin Receptor Signaling Pathway Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Symbiont Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration	Retina Homeostasis Nucleobase-containing Compound Metabolic Process Xenobiotic Metabolic Process Neurotransmitter Transport Xenobiotic Transmembrane Transport Pyrimidine Nucleobase Transport Purine Nucleoside Transmembrane Transport Uridine Transmembrane Transport Adenosine Transport Inosine Transport Azole Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport Purine Nucleobase Transmembrane Transport
Pathways		Ub-specific processing proteases Insulin receptor recycling Peroxisomal protein import Peroxisomal protein import	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Azathioprine ADME Ribavirin ADME
Drugs		Bacitracin
Diseases
GWAS		Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 27680694 31043758) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 20581827 22885922 24509480 26818947 29358691 30297969 30718926 32499647) Waist-to-hip ratio adjusted for BMI ( 28552196)	Estimated glomerular filtration rate ( 31015462) Uric acid levels ( 22229870) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5
Entrez ID		3416	9153
HPRD ID		00894	07069
Ensembl ID		ENSG00000119912	ENSG00000137860
Uniprot IDs		A0A3B3ISG5 A0A7I2V2P6 A0A7I2V373 B3KSB8 P14735	O43868 Q2M2A7 Q53H72
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3 7K1D 7K1E 7K1F 7RZE 7RZF 7RZG 7RZH 7RZI
Enriched GO Terms of Interacting Partners?		Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Regulation Of Glucose Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Growth Regulation Of Developmental Growth Receptor Ligand Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Glycolytic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Cellular Response To Oxygen-containing Compound Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Exocrine Pancreas Development Positive Regulation Of Growth Insulin Receptor Signaling Pathway Regulation Of Purine Nucleotide Metabolic Process Estrogen Response Element Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cell Cycle Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Proteolysis Beta-endorphin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Protein-containing Complex Binding Bradykinin Catabolic Process Ubiquitin Recycling Cytosolic Proteasome Complex Insulin Catabolic Process Insulin Binding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Prevention Of Polyspermy Trans-synaptic Signaling By BDNF Serine Protease Inhibitor Complex Regulation Of Body Fluid Levels Negative Regulation Of Plasminogen Activation Cellular Response To Thyroglobulin Triiodothyronine Response To Thyroglobulin Triiodothyronine Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Labyrinthine Layer Morphogenesis Carbon Catabolite Regulation Of Transcription Positive Regulation Of Female Receptivity Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Female Receptivity Female Mating Behavior Regulation Of Proteolysis Positive Regulation Of Protein Binding Peptidase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasminogen Activation Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Fertilization Peroxisome Proliferator Activated Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Estrous Cycle Smooth Muscle Cell Migration Positive Regulation Of Adipose Tissue Development Hormone Catabolic Process Hypothalamus Development Insulin Metabolic Process Peptide Catabolic Process Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Nuclear Retinoid X Receptor Binding Ovulation Cycle Nuclear Retinoic Acid Receptor Binding Regulation Of Biological Quality Negative Regulation Of Protein Metabolic Process Fibrinolysis
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