C2orf74 and TMEM17

Data Source: HiPPIP (Novel)

		C2orf74	TMEM17
Name		chromosome 2 open reading frame 74	transmembrane protein 17
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Cilium Membrane Ciliary Transition Zone MKS Complex Cell Projection Ciliary Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	None	Smoothened Signaling Pathway Cell Projection Organization Cilium Assembly Non-motile Cilium Assembly
GWAS		Crohn's disease ( 21102463 22412388 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Inflammatory bowel disease ( 23128233 )	Coronary artery disease ( 33020668 ) Crohn's disease ( 22412388 ) Low density lipoprotein cholesterol levels ( 33339817 ) Mean corpuscular hemoglobin concentration ( 29403010 ) Mean corpuscular volume ( 29403010 ) Number of sexual partners ( 30643258 ) Platelet distribution width ( 32888494 ) Prostate cancer ( 31562322 ) Schizophrenia ( 33169155 ) Total cholesterol levels ( 33339817 )
Novel Interactors		4 novel interactors: AHSA2P COMMD1 PNPT1 TMEM17	1 novel interactors: C2orf74
Interacting Genes		2 interacting genes: POT1 SMAGP	4 interacting genes: EHHADH SDCBP SS18L2 YIF1A
Entrez ID		339804	200728
HPRD ID		19550	15528
Ensembl ID		ENSG00000237651	ENSG00000186889
Uniprot IDs		A8MZ97 C9JBF1	Q86X19
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Nuclear Polyadenylation-dependent MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Positive Regulation Of Cholesterol Import Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Endosome To Plasma Membrane Protein Transport Telomeric D-loop Binding Telomere Assembly Mitochondrial MRNA Polyadenylation Mitochondrial RNA 5'-end Processing Regulation Of Plasma Lipoprotein Particle Levels Single-stranded Telomeric DNA Binding RNA Import Into Mitochondrion Regulation Of Cholesterol Import Shelterin Complex Mitochondrial RNA 3'-end Processing Exoribonuclease Complex Positive Regulation Of MiRNA Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Mitochondrial RNA Catabolic Process DEAD/H-box RNA Helicase Binding Poly(G) Binding Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Negative Regulation Of Sodium Ion Transmembrane Transport G-rich Strand Telomeric DNA Binding Plasma Membrane To Endosome Transport Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Protein Localization To Cell Surface MKS Complex Negative Regulation Of Cellular Response To Hypoxia Protein Homotrimerization Negative Regulation Of Sodium Ion Transport Response To Growth Hormone Low-density Lipoprotein Particle Clearance Regulation Of DNA Strand Elongation	Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of Extracellular Exosome Assembly