KRTAP19-5 and PRKAG3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP19-5	PRKAG3
Description		keratin associated protein 19-5	protein kinase AMP-activated non-catalytic subunit gamma 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Binding	Nucleotide Binding AMP-activated Protein Kinase Activity Protein Binding ATP Binding AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process		Regulation Of Glycolytic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Nutrient Levels Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Gluconeogenesis Regulation Of Cell Cycle
Pathways		Keratinization	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol ( 25961943) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Triglyceride levels ( 32203549 33339817)
Interacting Genes		97 interacting genes: ANKHD1 APOBEC1 ARID5A ATN1 ATOSB ATPAF2 BHLHE40 C11orf16 CAMK2A CAMK2B CATSPER1 CCDC17 CELF5 CHRD COL8A1 CRACR2A CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRT3 DMRTB1 EFEMP2 ENKD1 ESRP1 EVX2 FAM168A GLIS2 GLYCTK GPANK1 GRINA GUCD1 HAPLN2 HGS HOXB9 HYPK INCA1 KIFC3 KPRP KRT34 KRTAP12-4 KRTAP15-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MAGED1 MAPK1IP1L MGAT5B MYOZ3 MYPOP OIP5 OLIG3 OXER1 P4HA3 PATZ1 PITX1 PITX2 PLSCR4 POU2AF1 PPP1R16A PRKAG3 PRPF31 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSMB2 PSMB4 RBPMS RBPMS2 RHOXF2 RNF38 RNF44 RTP5 RUSC1 SAXO4 SEMA3B SNRPC SOHLH1 SPMIP6 SPMIP9 TCF7L2 TEKT3 TLE5 TNIP1 TSPYL6 UBQLN2 VAC14 VEZF1 VPS37C ZBTB32 ZIC1 ZNF414	6 interacting genes: BRCA1 CRYAB KRTAP19-5 LMCD1 NGRN PRKAA1
Entrez ID		337972	53632
HPRD ID		11209	16085
Ensembl ID		ENSG00000186977	ENSG00000115592
Uniprot IDs		Q3LI72	Q9UGI9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Axonemal A Tubule Inner Sheath Identical Protein Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Myoblast Fate Commitment Sperm Flagellum Spinal Cord Motor Neuron Migration Proteasome Core Complex Nucleus Calcium- And Calmodulin-dependent Protein Kinase Complex Chromatin Intermediate Filament	Response To Ionizing Radiation Protein K6-linked Ubiquitination Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Gamma Radiation Negative Regulation Of Lipid Biosynthetic Process Response To Radiation Cellular Response To Ionizing Radiation Negative Regulation Of Glucosylceramide Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Fatty Acid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Response To Hydrogen Peroxide Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process BRCA1-B Complex Negative Regulation Of Cell Growth Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Cellular Response To Radiation Protein-containing Complex Response To Indole-3-methanol Regulation Of Lipid Biosynthetic Process Response To Reactive Oxygen Species Response To Temperature Stimulus Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Cold Acclimation Positive Regulation Of Mitochondrial Transcription Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Positive Regulation Of Translation Protein Localization To Lipid Droplet CAMKK-AMPK Signaling Cascade Mitochondrial Ribosome Assembly Negative Regulation Of Centriole Replication Negative Regulation Of Growth Negative Regulation Of Apoptotic Process Cardiac Myofibril Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of Programmed Cell Death BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Protein Stabilization
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