EIF4E3 and AANAT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF4E3	AANAT
Description		eukaryotic translation initiation factor 4E family member 3	aralkylamine N-acetyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding	Aralkylamine N-acetyltransferase Activity Arylamine N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups 14-3-3 Protein Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation	N-terminal Protein Amino Acid Acetylation Circadian Rhythm Response To Light Stimulus Photoperiodism Response To Zinc Ion Melatonin Biosynthetic Process Response To Insulin Response To Cytokine Response To Prostaglandin E Indolalkylamine Biosynthetic Process Response To Copper Ion Rhythmic Process Response To Corticosterone Response To CAMP Response To Calcium Ion Cellular Response To CAMP Response To Peptide
Pathways		ISG15 antiviral mechanism	Serotonin and melatonin biosynthesis
Drugs			CoA-S-trimethylene-acetyl-tryptamine CoA-s-acetyl tryptamine CoA-S-acetyl 5-bromotryptamine Cannabidiol Medical Cannabis Nabiximols
Diseases			Delayed sleep phase syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Cutaneous squamous cell carcinoma ( 32041948) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Nose size ( 27182965) Type 2 diabetes ( 31049640)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		2 interacting genes: AANAT CFTR	8 interacting genes: BHLHE40 EIF4E3 F2 GRB10 KRTAP8-1 MDFI PRKACA YWHAZ
Entrez ID		317649	15
HPRD ID		10687	02974
Ensembl ID		ENSG00000163412	ENSG00000129673
Uniprot IDs		Q8N5X7	F1T0I5 Q16613
PDB IDs			6T80
Enriched GO Terms of Interacting Partners?		14-3-3 Protein Binding Cellular Response To CAMP Response To CAMP Indolalkylamine Biosynthetic Process Response To Purine-containing Compound Melatonin Biosynthetic Process Aralkylamine N-acetyltransferase Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Ketone Response To Alcohol Positive Regulation Of Anion Channel Activity Arylamine N-acetyltransferase Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Hormone Levels Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity N-terminal Protein Amino Acid Acetylation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane N-acetyltransferase Activity Cellular Response To Forskolin Response To Corticosterone Response To Forskolin Response To Lipid Chloride Transmembrane Transporter Activity Sperm Capacitation Cellular Response To Oxygen-containing Compound Bicarbonate Transport Water Transport Response To Prostaglandin E Photoperiodism Multicellular Organismal-level Water Homeostasis Protein Acetylation Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Response To Copper Ion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Survivin Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process ERK1 And ERK2 Cascade Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Macromolecule Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Negative Regulation Of TOR Signaling TOR Signaling Synaptic Target Recognition Regulation Of TORC1 Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Regulation Of Metabolic Process Regulation Of Sequestering Of Calcium Ion Blood Microparticle Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Thrombospondin Receptor Activity Regulation Of Generation Of Precursor Metabolites And Energy Vascular Associated Smooth Muscle Cell Migration Tube Formation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Interphase Microtubule Organizing Center Regulation Of Gene Expression Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Golgi Reassembly MRF Binding Regulation Of TOR Signaling Regulation Of Cell Communication Negative Regulation Of DNA-templated Transcription Chromosome Passenger Complex Regulation Of Signaling Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization To Nucleus
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