HLX and MIEN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HLX	MIEN1
Description		H2.0 like homeobox	migration and invasion enhancer 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding	Protein Binding
	Biological Process	Liver Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Skeletal Muscle Tissue Development Cell Population Proliferation Cell Differentiation Organ Growth T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Organ Growth Enteric Nervous System Development Animal Organ Development Embryonic Digestive Tract Morphogenesis Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation	Apoptotic Process Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Process Positive Regulation Of Filopodium Assembly
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid AB1-42 levels ( 26252872) Diverticular disease ( 30177863) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FVC) ( 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) PR interval ( 32439900) Triglyceride levels ( 32154731) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) White blood cell count ( 32888494)	Asthma ( 29273806 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Systemic lupus erythematosus ( 28714469)
Interacting Genes		13 interacting genes: ATXN1L C14orf119 CALCOCO2 CYSRT1 DTX2 FOXH1 LONRF1 MIEN1 PRR20A PRR20B PRR20C PRR20D PRR20E	15 interacting genes: ARID5A DDIT4L GORASP2 HDAC7 HIVEP1 HLX HMGB1 HMGB2 NLGN3 POU6F2 REL RNF126 TRIP6 VENTX ZBTB32
Entrez ID		3142	84299
HPRD ID		00875	12681
Ensembl ID		ENSG00000136630	ENSG00000141741
Uniprot IDs		Q14774	J3KTI2 Q9BRT3
PDB IDs			2LJK
Enriched GO Terms of Interacting Partners?			DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Geometric Change Supercoiled DNA Binding Regulation Of Interferon-beta Production Regulation Of Nucleobase-containing Compound Metabolic Process DNA Topological Change Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RAGE Receptor Binding Regulation Of Cytokine Production Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process T-helper 1 Cell Differentiation Regulation Of Non-canonical NF-kappaB Signal Transduction DNA Binding, Bending DNA Conformation Change Four-way Junction DNA Binding V(D)J Recombination Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Type I Interferon Production Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Inflammatory Response To Antigenic Stimulus Chemoattractant Activity Condensed Chromosome Cellular Response To Lipopolysaccharide Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding T-helper Cell Differentiation Positive Regulation Of Interferon-beta Production DNA-binding Transcription Factor Binding Cellular Response To Molecule Of Bacterial Origin T Cell Differentiation Involved In Immune Response Positive Regulation Of Epithelial Cell Proliferation Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Somatic Cell DNA Recombination Positive Chemotaxis Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Adaptive Immune Response
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