MR1 and NINJ2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MR1	NINJ2
Description		major histocompatibility complex, class I-related	ninjurin 2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane MHC Class I Protein Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Beta-2-microglobulin Binding MHC Class I Receptor Activity T Cell Receptor Binding	Protein Binding Cholesterol Binding Membrane Destabilizing Activity
	Biological Process	Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Immunity Positive Regulation Of T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Antigen Processing And Presentation Of Exogenous Antigen T Cell Differentiation In Thymus Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Cell Adhesion Neuron Cell-cell Adhesion Nervous System Development Cytolysis Tissue Regeneration
Pathways
Drugs		Antithymocyte immunoglobulin (rabbit)
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Post bronchodilator FEV1 ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte count ( 27863252 32888494) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Rheumatic heart disease ( 34106200) Stroke ( 19369658) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CDS2 CXCL9 EMP3 ERMP1 FATE1 GALNT15 NINJ2	79 interacting genes: AMIGO1 AQP6 ARL13B BCL2L13 BTNL9 CD69 CD79A CEACAM3 CHODL CLEC17A CLEC7A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ELOVL5 EREG ERGIC3 ERVFRD-1 EVI2B FAM209A FAM210B FCGRT FCRL4 FNDC9 GJA1 GJA8 GPR152 GPR42 GPX8 ICAM3 IFNGR1 IL3RA JAGN1 KCNJ6 KIR2DL3 KIR3DL3 LDLRAD1 LHFPL5 LMNA LYPD5 LYVE1 M6PR MGST3 MMGT1 MR1 MUC1 ODF4 PIGP PVR REEP4 RIC3 RNASEK SCN3B SLAMF8 SLC10A1 SLC10A6 SLC35H1 SLC66A1 SLC7A14 SLC7A8 SSMEM1 STX1A STX2 TM4SF20 TMEM101 TMEM139 TMEM14B TMEM31 TMEM51 TMEM52B TMEM86B TMEM9 TMPRSS2 TMX2 TSPAN12 VMA21 VSIG1
Entrez ID		3140	4815
HPRD ID		09012	09530
Ensembl ID		ENSG00000153029	ENSG00000171840
Uniprot IDs		A0A8C8PVM5 Q95460	A0A590UJR9 B4DJC1 F5H3L1 F8WBZ3 Q9NZG7
PDB IDs		4GUP 4L4T 4L4V 4LCW 4NQC 4NQD 4NQE 4PJ5 4PJ7 4PJ8 4PJ9 4PJA 4PJB 4PJC 4PJD 4PJE 4PJF 4PJG 4PJH 4PJI 4PJX 5D5M 5D7I 5D7J 5D7L 5U16 5U17 5U1R 5U2V 5U6Q 5U72 6MWR 6PUC 6PUD 6PUE 6PUF 6PUG 6PUH 6PUI 6PUJ 6PUK 6PUL 6PUM 6PVC 6PVD 6W9U 6W9V 6XQP 7LLI 7LLJ 7RNO 7UFJ 7UMG 7ZT2 7ZT3 7ZT4 7ZT5 7ZT7 7ZT8 7ZT9 8BP6 8Y6X 9BTX 9BTY 9BTZ 9BU0 9CGR 9CGS	8SZB
Enriched GO Terms of Interacting Partners?			Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Intracellular PH Reduction External Side Of Plasma Membrane Bile Acid:sodium Symporter Activity Lysosomal Lumen Acidification
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