ZBTB44 and POLI

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ZBTB44	POLI
Name		zinc finger and BTB domain containing 44	DNA polymerase iota
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	None	DNA Replication DNA Repair DNA Damage Response Translesion Synthesis Error-prone Translesion Synthesis DNA Biosynthetic Process
Pathways		None	Translesion synthesis by POLI Termination of translesion DNA synthesis
GWAS		Diastolic blood pressure ( 27841878 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 )	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Asthma ( 30929738 31361310 32296059 ) Asthma (childhood onset) ( 30929738 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory skin disease ( 25574825 )
Interacting Genes		18 interacting genes: AP1M1 ENO1 ERG ETS2 FAM124A FBXO7 GLRX3 HUNK POLI PSMA6 RAD23A RSPH1 SMAD1 SMAD7 SMURF2 SMYD1 TIAM1 WDFY3	22 interacting genes: APP CALCOCO2 DAZAP2 DVL2 EP300 HOMER3 MFHAS1 MTNR1B NEDD8 PCNA POLH REV1 RNF11 TMEM239 TRAF6 TRIM23 TRIM39 UBA52 UBB UBC USP7 ZBTB44
Entrez ID		29068	11201
HPRD ID		13692	16094
Ensembl ID		ENSG00000196323	ENSG00000101751
Uniprot IDs		H0YEM9 Q8NCP5	J3KQ09 J3KSW2 Q9UNA4
PDB IDs		Not available	1T3N 1ZET 2ALZ 2DPI 2DPJ 2FLL 2FLN 2FLP 2KHU 2KHW 2KTF 2L0F 2L0G 2MBB 3EPG 3EPI 3G6V 3G6X 3G6Y 3GV5 3GV7 3GV8 3H40 3H4B 3H4D 3NGD 3OSN 3Q8P 3Q8Q 3Q8R 3Q8S 4EBC 4EBD 4EBE 4EYH 4EYI 4FS1 4FS2 5KT2 5KT3 5KT4 5KT5 5KT6 5KT7 5ULW 5ULX
GO Terms Enriched among Interactors		Cytosol Cell Fate Commitment Involved In Formation Of Primary Germ Layer Heteromeric SMAD Protein Complex I-SMAD Binding Positive Regulation Of Proteolysis Transcription Corepressor Activity Nucleus Ureteric Bud Development SMAD Protein Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Cartilage Development Mesonephric Tubule Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Purine Ribonucleoside Triphosphate Binding Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasomal Protein Catabolic Process	Protein Tag Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Damaged DNA Binding Ubiquitin Protein Ligase Binding Translesion Synthesis Positive Regulation Of JNK Cascade Protein Modification Process Postreplication Repair Regulation Of Signal Transduction By P53 Class Mediator Error-free Translesion Synthesis DNA Synthesis Involved In DNA Repair Nucleus Regulation Of JNK Cascade DNA Damage Response Response To UV Response To Light Stimulus Error-prone Translesion Synthesis Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis P53 Binding Endocytic Vesicle Membrane Response To Radiation Cellular Response To UV DNA Biosynthetic Process Autophagosome Assembly Negative Regulation Of Gluconeogenesis Stimulatory C-type Lectin Receptor Signaling Pathway Autophagosome Organization Cellular Response To Lectin Cellular Response To Light Stimulus DNA-directed DNA Polymerase Activity Protein Metabolic Process Protein Serine/threonine Kinase Binding Endosome Membrane Macromolecule Metabolic Process Replication Fork Modification-dependent Protein Catabolic Process Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Protein Localization