HAPSTR1 and INTS12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HAPSTR1	INTS12
Description		HUWE1 associated protein modifying stress responses	integrator complex subunit 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Integrator Complex INTAC Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Cellular Response To Stress Negative Regulation Of Signal Transduction By P53 Class Mediator	SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing RNA Polymerase II Transcription Initiation Surveillance
Pathways			RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS			Asthma ( 31959851) Chronic obstructive pulmonary disease ( 30804561) Lung function (FEV1) ( 24023788) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Weight ( 28548082)
Interacting Genes		2 interacting genes: FAM9B INTS12	4 interacting genes: APP CEBPA FAM9A HAPSTR1
Entrez ID		29035	57117
HPRD ID		17910	11271
Ensembl ID		ENSG00000182831	ENSG00000138785
Uniprot IDs		Q14CZ0	Q96CB8
PDB IDs
Enriched GO Terms of Interacting Partners?		SnRNA 3'-end Processing Integrator Complex INTAC Complex RNA Polymerase II Transcription Initiation Surveillance Synaptonemal Complex SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Development Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Maturation Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling White Fat Cell Proliferation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Learning Or Memory Axon Choice Point Recognition Response To Phenylpropanoid
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