IGSF10 and EIF2A

		IGSF10	EIF2A
Description		immunoglobulin superfamily member 10	eukaryotic translation initiation factor 2A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Space Cytoplasm Eukaryotic Translation Initiation Factor 2 Complex Blood Microparticle
	Molecular Function		TRNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding Cadherin Binding
	Biological Process	Ossification Cell Differentiation Regulation Of Neuron Migration	Translation Translational Initiation Regulation Of Translation Positive Regulation Of Signal Transduction SREBP Signaling Pathway Ribosome Assembly Response To Amino Acid Starvation
Pathways
Drugs		Pyridoxal phosphate
Diseases
GWAS		Refractive error ( 32231278)	Metabolite levels ( 23823483)
Interacting Genes		1 interacting genes: APP	7 interacting genes: APP BZW2 CEBPA EIF2AK2 MARK2 MLH1 RNF4
Entrez ID		285313	83939
HPRD ID		13732	11739
Ensembl ID		ENSG00000152580	ENSG00000144895
Uniprot IDs		Q6WRI0	F8WAE5 Q9BY44
PDB IDs			8DYS
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Cellular Response To Sterol Depletion SREBP Signaling Pathway Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Regulation Of Translation Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Regulation Of Hematopoietic Stem Cell Proliferation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Intermediate-density Lipoprotein Particle Positive Regulation Of Chemokine Production Positive Regulation Of Inflammatory Response Regulation Of Cell Activation Regulation Of Developmental Process Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Gene Expression NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Response To Peptide Response To Cytokine Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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