SPRYD4 and EEF1B2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPRYD4	EEF1B2
Description		SPRY domain containing 4	eukaryotic translation elongation factor 1 beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Protein Binding	Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process		Translation Translational Elongation Response To Ethanol
Pathways			Eukaryotic Translation Elongation
Drugs
Diseases
GWAS		Axial length ( 24144296) Blood urea nitrogen levels ( 31152163) Lipoprotein (a) levels ( 33730874) Metabolite levels ( 22916037) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 23093944)	Body mass index ( 26426971)
Interacting Genes		1 interacting genes: EEF1B2	15 interacting genes: AARS1 APP CEBPA CSNK2A1 CSNK2A2 DRD3 EEF1G HARS1 SPRYD4 TIMP1 TPT1 ULK2 USP7 VHL WBP2
Entrez ID		283377	1933
HPRD ID		11251	02804
Ensembl ID		ENSG00000176422	ENSG00000114942
Uniprot IDs		Q8WW59	P24534
PDB IDs			1B64 5DQS
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Elongation Factor 1 Complex Translation Elongation Factor Activity Translational Elongation Response To Ethanol	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Proteolysis Regulation Of Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Collateral Sprouting Regulation Of Neurotransmitter Uptake Regulation Of Signal Transduction By P53 Class Mediator Protein Serine/threonine Kinase Binding Regulation Of Protein Metabolic Process Regeneration Regulation Of Membrane Protein Ectodomain Proteolysis Signal Transduction PcG Protein Complex Cellular Response To Stress Amyloid Fibril Formation Protein Metabolic Process Cytosol TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity DNA-binding Transcription Factor Binding TRNA Aminoacylation Response To Stress Macromolecule Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity
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