SPINK4 and SIGMAR1

		SPINK4	SIGMAR1
Description		serine peptidase inhibitor Kazal type 4	sigma non-opioid intracellular receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Postsynaptic Density Membrane Growth Cone Cytoplasmic Vesicle Cell Projection Synapse Postsynaptic Membrane Anchoring Junction Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	G Protein-coupled Opioid Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Response To Xenobiotic Stimulus	Lipid Transport Nervous System Development G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization Regulation Of Postsynapse Assembly
Pathways			Potential therapeutics for SARS
Drugs			Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Naltrexone Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Pimavanserin Noscapine Captodiame Pentoxyverine
Diseases
GWAS		Influenza A (H1N1) infection ( 26379185) Mild influenza (H1N1) infection ( 26379185) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		1 interacting genes: SGTB	5 interacting genes: ANK2 GHSR ITPR3 PDZD11 SRI
Entrez ID		27290	10280
HPRD ID		11598	03580
Ensembl ID		ENSG00000122711	ENSG00000147955
Uniprot IDs		O60575 V9HWG8	A0A7P0T9D5 A0A7P0Z4C2 B4DR71 Q99720
PDB IDs			5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?		Protein Homooligomerization Protein Complex Oligomerization TRC Complex G Protein-coupled Opioid Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homotrimerization Protein Trimerization Nuclear Outer Membrane Protein Targeting To ER Protein Heterooligomerization Establishment Of Protein Localization To Endoplasmic Reticulum Nuclear Inner Membrane Protein-containing Complex Assembly Regulation Of Postsynapse Assembly Hsp70 Protein Binding Protein-containing Complex Organization Protein Targeting To Membrane Lipid Droplet Identical Protein Binding Postsynaptic Density Membrane Protein-folding Chaperone Binding
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