DKKL1 and C11orf71

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DKKL1	C11orf71
Description		dickkopf like acrosomal protein 1	chromosome 11 open reading frame 71
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Cytoplasmic Vesicle
	Molecular Function	Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Penetration Of Zona Pellucida Anatomical Structure Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Testosterone Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088 24076602)	Asthma ( 21804549 29273806)
Interacting Genes		2 interacting genes: C11orf71 FJX1	3 interacting genes: APP DKKL1 GPRC5B
Entrez ID		27120	54494
HPRD ID		10396	07874
Ensembl ID		ENSG00000104901	ENSG00000180425
Uniprot IDs		A0A140VK15 Q9UK85	A0A0A8K8C2 Q6IPW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Retina Layer Formation	Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation G Protein-coupled Receptor Binding Cytoplasmic Vesicle Positive Regulation Of Cell Differentiation Acetylcholine Receptor Activator Activity Membrane Raft PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Inflammatory Response Regulation Of Neuron Differentiation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Developmental Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Testosterone Biosynthetic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Extracellular Space Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Phosphate Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Axon Choice Point Recognition
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