ST6GALNAC4 and SPATA20

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ST6GALNAC4	SPATA20
Gene Name		ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	spermatogenesis associated 20
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	Sialyltransferase Activity (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase Activity	Catalytic Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Glycolipid Metabolic Process O-glycan Processing Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation	Multicellular Organismal Development Spermatogenesis Metabolic Process Cell Differentiation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) O-linked glycosylation Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SPATA20	3 interactors: CORO1A ST6GALNAC4 XRN1
Entrez ID		27090	64847
HPRD ID		05902	07961
Ensembl ID		ENSG00000136840	ENSG00000006282
Uniprot IDs		A8K7N4 Q9H4F1	Q8TB22
PDB IDs
Enriched GO Terms of Interacting Partners?			Early Endosome To Recycling Endosome Transport Uropod Organization Negative Regulation Of Vesicle Fusion Nuclear MRNA Surveillance RNA Surveillance Phagolysosome Assembly Histone MRNA Catabolic Process Nerve Growth Factor Signaling Pathway RRNA Catabolic Process Negative Regulation Of Actin Nucleation Histone MRNA Metabolic Process Regulation Of Actin Nucleation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Response To Nerve Growth Factor Stimulus Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Positive Chemotaxis Regulation Of Vesicle Fusion T Cell Homeostasis Homeostasis Of Number Of Cells Within A Tissue Phagosome Maturation Cellular Response To Interleukin-4 O-glycan Processing Response To Interleukin-4 Lysosome Organization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Sialylation Dolichol-linked Oligosaccharide Biosynthetic Process
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