ELP4 and ELP6

Number of citations of the paper that reports this interaction (PubMedID 36617428)
102

Data Source:
BioGRID (pull down)

		ELP4	ELP6
Description		elongator acetyltransferase complex subunit 4	elongator acetyltransferase complex subunit 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	Protein Binding Phosphorylase Kinase Regulator Activity	Protein Binding
	Biological Process	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Regulation Of Translation TRNA Processing	TRNA Wobble Uridine Modification Translation Regulation Of Translation Protein Folding Autophagy Apoptotic Process Response To Unfolded Protein Locomotory Behavior TRNA Processing Ubiquitin Recycling Positive Regulation Of Cell Migration Cellular Response To Stress Photoreceptor Cell Differentiation Homeostasis Of Number Of Retina Cells Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Retina Development In Camera-type Eye Motor Behavior Autophagosome Maturation Inflammasome-mediated Signaling Pathway
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Glaucoma ( 25027321) Mental health study participation (completed survey) ( 31263887) Optic disc area ( 25631615) Optic disc size ( 31809533) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Refractive error ( 32231278)
Interacting Genes		4 interacting genes: ELP5 ELP6 HINFP PPP1CC	7 interacting genes: CLK1 ELP1 ELP2 ELP3 ELP4 MLH1 SRPK2
Entrez ID		26610	54859
HPRD ID		07377	07884
Ensembl ID		ENSG00000109911	ENSG00000163832
Uniprot IDs		G5E9D4 Q96EB1	C9IYN7 Q0PNE2
PDB IDs
Enriched GO Terms of Interacting Partners?		Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Metabolic Process Squalene Synthase [NAD(P)H] Activity Inflammasome-mediated Signaling Pathway TRNA Uridine(34) Acetyltransferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity TRNA Binding Regulation Of Translation Cytoplasmic Pattern Recognition Receptor Signaling Pathway N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Homeostasis Of Number Of Retina Cells TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility N-acetylglucosamine Catabolic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Locomotion Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Farnesyl Diphosphate Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Ubiquitin Recycling Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Catabolic Process PTW/PP1 Phosphatase Complex Innate Immune Response-activating Signaling Pathway Protein Linear Polyubiquitination Activation Of Innate Immune Response Intracellular Receptor Signaling Pathway UDP-N-acetylglucosamine Biosynthetic Process MAPK Cascade RNA Processing Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Intracellular Signal Transduction	Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity TRNA Metabolic Process RNA Metabolic Process RNA Processing Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Elongation Factor Complex Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment TRNA Uridine(34) Acetyltransferase Activity TRNA Binding Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Male Meiosis Chromosome Segregation MutLalpha Complex Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Speck Organization Regulation Of Nucleobase-containing Compound Metabolic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing MutSalpha Complex Binding Regulation Of Mitotic Recombination Regulation Of Protein Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization R-loop Processing Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes PERK-mediated Unfolded Protein Response
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