EHF and GDF15

		EHF	GDF15
Description		ETS homologous factor	growth differentiation factor 15
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Golgi Apparatus	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Epithelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung disease severity in cystic fibrosis ( 26417704) Obesity-related traits ( 23251661) Prostate-specific antigen levels ( 28139693) Response to antipsychotic treatment ( 21107309) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Systemic lupus erythematosus ( 24871463) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Volumetric brain MRI ( 17903297)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		2 interacting genes: APP FRZB	7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3
Entrez ID		26298	9518
HPRD ID		16105	05608
Ensembl ID		ENSG00000135373	ENSG00000130513
Uniprot IDs		Q9NZC4	Q99988
PDB IDs			5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Response To Interleukin-1 Growth Cone Lamellipodium Regulation Of Growth Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Interleukin-6 Production Amylin Binding Positive Regulation Of JNK Cascade Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Negative Regulation Of Hepatocyte Differentiation Response To Metformin Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of JNK Cascade Regulation Of Developmental Process Regulation Of Interleukin-6 Production Cell Development Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Cell Differentiation Myeloid Leukocyte Activation Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Leukocyte Migration Regulation Of Signal Transduction Axon Midline Choice Point Recognition Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?